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运动通过脂噬作用调节脂代谢及其分子机制

李梦影¹, 李灵杰², 马春伟¹, 高炳宏^2,*

¹上海体育学院运动科学学院，上海 200438；²上海体育学院体育教育训练学院，上海 200438

摘要

脂噬是一种选择性的自噬，可以选择性地识别并降解脂滴，在调节细胞脂代谢、维持细胞内脂质稳态中发挥重要作用。运动能够诱导脂噬，同时也是减控体脂的有效手段。本文将重点介绍运动与肝脏、胰腺、脂肪组织等重要脏器脂噬作用的联系，并总结归纳运动调控脂噬作用的分子机制，为采取运动方式防治脂肪肝、肥胖等相关代谢性疾病提供一种新的思路。

关键词： 脂噬; 运动; 肥胖; 脂代谢

Exercise regulates lipid metabolism via lipophagy and its molecular mechanisms 

LI Meng-Ying¹, LI Ling-Jie², MA Chun-Wei¹, GAO Bing-Hong^2,*

¹School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China；²School of Physical Training, Shanghai University of Sport, Shanghai 200438, China

Abstract

Lipophagy is a kind of selective autophagy, which can selectively identify and degrade lipid droplets and plays an important role in regulating cellular lipid metabolism and maintaining intracellular lipid homeostasis. Exercise can induce lipophagy and it is also an effective means of reducing body fat. In this review, we summarized the relationship between exercise and lipophagy in the liver, pancreas, adipose tissue, and the possible molecular mechanisms to provide a new clue for the prevention and treatment of fatty liver, obesity and other related metabolic diseases by exercise.

Key words: lipophagy; exercise; obesity; lipid metabolism

收稿日期：　　录用日期：

通讯作者：高炳宏　　E-mail: gaobinghong@126.com

DOI: 10.13294/j.aps.2021.0099

引用本文：

李梦影, 李灵杰, 马春伟, 高炳宏. 运动通过脂噬作用调节脂代谢及其分子机制[J]. 生理学报 2022; 74 (2): 309-319.

LI Meng-Ying, LI Ling-Jie, MA Chun-Wei, GAO Bing-Hong. Exercise regulates lipid metabolism via lipophagy and its molecular mechanisms . Acta Physiol Sin 2022; 74 (2): 309-319 (in Chinese with English abstract).