过刊浏览

Nogo-B受体的生物学功能

朱莹, 张利群, 李建东^*

中国人民解放军总医院第八医学中心，呼吸与危重症医学部，北京 100091

摘要

Nogo-B受体(Nogo-B receptor, NgBR)是网状蛋白家族4成员Nogo-B的受体，广泛分布于机体的多种组织和器官，并定位于细胞膜及内质网。NgBR参与了体内多种生理和病理生理过程，如多萜醇合成、脂肪代谢、胆固醇转运，以及胰岛素抵抗、血管重塑和生成、肿瘤形成和神经系统疾病等。本文拟对近年来关于NgBR的结构与功能做一简要综述。对NgBR的结构及功能的进一步探究，将有助于深入了解其参与各种疾病的作用机制，为疾病的防治提供可能的临床策略。

关键词： Nogo-B受体; Nogo-B; NUS1; 胆固醇转运; 肿瘤形成

Biological function of Nogo-B receptor 

ZHU Ying, ZHANG Li-Qu, LI Jian-Dong^*

Department of Respiratory and Critical Care Medicine, Eighth Medical Center of Chinese PLA General Hospital, Beijing 100091, China

Abstract

Nogo-B receptor (NgBR) is a specific receptor of Nogo-B, a member of reticulon 4 protein family. It is widely expressed in many tissues and mainly located in cell membrane and endoplasmic reticulum. Previous studies have revealed that NgBR is involved in a variety of physiological and pathophysiological processes, such as dolichol synthesis, lipid metabolism, cholesterol trafficking, insulin resistance, vascular remodeling and angiogenesis, tumorigenesis and nervous system diseases. Further studies on the molecular characteristics and biological function of NgBR might be of great significance to understand its role in diverse diseases and provide possible clinical strategies for the treatment of diseases.

Key words: Nogo-B receptor; Nogo-B; NUS1; cholesterol trafficking; tumorigenesis

收稿日期：　　录用日期：

通讯作者：李建东　　E-mail: lijdzyy@163.com

DOI: 10.13294/j.aps.2022.0017

引用本文：

朱莹, 张利群, 李建东. Nogo-B受体的生物学功能[J]. 生理学报 2022; 74 (2): 301-308.

ZHU Ying, ZHANG Li-Qu, LI Jian-Dong. Biological function of Nogo-B receptor . Acta Physiol Sin 2022; 74 (2): 301-308 (in Chinese with English abstract).