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III型固有淋巴细胞在炎症性疾病中的作用

谢慧欣^1,2, 郭赟^1,2, 钟豪杰^1,2, 周怡^2,*, 余学清^1,3

¹广东医科大学第一临床医学院，湛江 524023；²中山大学附属第一医院肾内科；国家卫生健康委员会肾脏病临床研究重点实验室；广东省肾脏病重点实验室，广州 510080；³广东省人民医院；广东省医学科学院，广州 510080

摘要

III型固有淋巴细胞(group 3 innate lymphoid cells, ILC3)是近十年才被定义的一群新型免疫细胞，属于固有淋巴细胞家族。ILC3包括多种表型和功能差异的细胞亚群，主要分布于肠道、肺及皮肤等屏障组织，在机体免疫调节、组织修复和淋巴组织形成中起重要作用。然而，在多种炎症性疾病中，ILC3出现数量和功能异常，可通过分泌白介素(interleukin, IL)-17、IL-22、γ-干扰素(interferon γ, IFN-γ)及粒-巨噬细胞集落刺激因子(granulocyte-macrophage colony-stimulating factor, GM-CSF)等致炎性细胞因子调控其他免疫细胞和诱导异位淋巴结构形成，从而促进疾病的发生和进展。因此，深入探究ILC3的表型及功能对拓展炎症性疾病的认识和寻找新的治疗靶点具有重要意义。本文就ILC3的表型特点、生物学功能及其在炎症性疾病中的研究进展进行综述。

关键词： III型固有淋巴细胞; 炎症性疾病; 细胞因子

Emerging pathogenic role of group 3 innate lymphoid cells in inflammatory diseases

XIE Hui-Xin^1,2, GUO Yun^1,2, ZHONG Hao-Jie^1,2, ZHOU Yi^2,*, YU Xue-Qing^1,3

¹The First Clinical Medical College, Guangdong Medical University, Zhanjiang 524023, China；²Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University; Key Laboratory of Nephrology, National Health Commission and Guangdong Province, Guangzhou 510080, China；³Guangdong Provincial People’s Hospital; Guangdong Academy of Medical Sciences, Guangzhou 510080, China

Abstract

Group 3 innate lymphoid cells (ILC3) as a family member of innate lymphoid cells (ILCs), have been defined as novel innate immune cells in the past decade. ILC3 include a variety of heterogenous subsets with different phenotypes and functions, which are mainly distributed in barrier organs such as the intestine, lung and skin. They play an important role in immune regulation, tissue repair and lymphoid tissue formation. However, in various inflammatory diseases, ILC3 become dysregulated and participate in the pathogenesis through secreting a series of cytokines such as interleukin (IL)-17, IL-22, interferon-γ (IFN-γ) and granulocyte-macrophage colony-stimulating factor (GM-CSF) to modulate other immune cells and induce the formation of ectopic lymphoid structures. Therefore, it is of great significance to explore the phenotype and function of ILC3 in order to advance the understanding of inflammatory diseases and find new therapeutic targets. In this article, the phenotypic characteristics, biological functions and research progress of ILC3 in inflammatory diseases were reviewed.

Key words: group 3 innate lymphoid cells; inflammatory diseases; cytokines

收稿日期：　　录用日期：

通讯作者：周怡　　E-mail: zhouyi39@mail.sysu.edu.cn

DOI: 10.13294/j.aps.2022.0012

引用本文：

谢慧欣, 郭赟, 钟豪杰, 周怡, 余学清. III型固有淋巴细胞在炎症性疾病中的作用[J]. 生理学报 2022; 74 (2): 265-275.

XIE Hui-Xin, GUO Yun, ZHONG Hao-Jie, ZHOU Yi, YU Xue-Qing. Emerging pathogenic role of group 3 innate lymphoid cells in inflammatory diseases. Acta Physiol Sin 2022; 74 (2): 265-275 (in Chinese with English abstract).