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线粒体自噬相关受体蛋白研究进展

马穰桂¹, 夏志^2,3, 尚画雨^1,*

¹成都体育学院运动医学与健康学院，成都 610041；²温州大学体育与健康学院，温州 325035；³冈山大学体育学院，吉安 343009

摘要

细胞通过自噬方式选择性清除多余或损伤的线粒体，是细胞内线粒体质量控制的重要机制。近期研究表明，酵母细胞主要通过自噬相关基因(Atgs)调控线粒体自噬，而哺乳动物细胞内则由PTEN诱导激酶1 (PTEN-induced putative kinase 1, PINK1)、NIX/BNIP3L、BNIP3、FUNDC1 (FUN14 domain containing 1)、FKBP8/FKBP38、Bcl-2样蛋白13 (Bcl-2-like protein 13, Bcl2L13)、含核苷酸结合结构域和富亮氨酸重复序列的蛋白家族成员X1 (NLRX1)、抗增殖蛋白(PHB2)等线粒体膜相关蛋白和心磷脂(cardiolipin, CL)等脂类作为介导线粒体自噬的关键受体而选择性识别受损的线粒体，并通过与微管相关蛋白1轻链3 (microtubule-associated protein 1 light chain 3, LC3)或γ-氨基丁酸受体相关蛋白(γ-aminobutyric acid receptor-associated protein, GABARAP)结合将其包裹在自噬体内，最终被溶酶体降解清除。本文对线粒体自噬相关受体蛋白的近期研究进展进行综述。

关键词： 线粒体; 细胞自噬; 线粒体自噬; 受体

分类号：R3;Q4;Q5

Advances in the study of mitophagy-related receptor proteins

MA Rang-Gui¹, XIA Zhi^2,3, SHANG Hua-Yu^1,*

¹School of Sports Medicine and Health, Chengdu Sport University, Chengdu 610041, China；²College of Physical Education and Health, Wenzhou University, Wenzhou 325035, China；³Physical Education College of Jinggangshan University, Ji’an 343009, China

Abstract

Cells selectively scavenge redundant or damaged mitochondria by mitophagy, which is an important mechanism of mitochondrial quality control. Recent studies have shown that mitophagy is mainly regulated by autophagy-related genes (Atgs) in yeast cells, while mitochondrial membrane associated proteins such as PTEN-induced putative kinase 1 (PINK1), NIX/BNIP3L, BNIP3, FUN14 domain containing 1 (FUNDC1), FKBP8/FKBP38, Bcl-2-like protein 13 (Bcl2L13), nucleotide binding domain and leucine-rich-repeat-containing proteins X1 (NLRX1), prohibitin 2 (PHB2) and lipids such as cardiolipin (CL) are the key mitophagic receptors in mammalian cells, which can selectively recognize damaged mitochondria, recruit them into isolation membranes by binding to microtubule-associated protein 1 light chain 3 (LC3) or γ-aminobutyric acid receptor-associated protein (GABARAP), and then fuse with lysosomes to eliminate the trapped mitochondria. This article reviews recent research progress of mitophagy-related receptor proteins.

Key words: mitochondrion; autophagy; mitophagy; receptors

收稿日期：2021-01-27　　录用日期：2021-05-06

通讯作者：尚画雨　　E-mail: santanasan@163.com

引用本文：

马穰桂, 夏志, 尚画雨. 线粒体自噬相关受体蛋白研究进展[J]. 生理学报 2021; 73 (6): 1025-1034.

MA Rang-Gui, XIA Zhi, SHANG Hua-Yu. Advances in the study of mitophagy-related receptor proteins. Acta Physiol Sin 2021; 73 (6): 1025-1034 (in Chinese with English abstract).