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糖脂代谢稳态调节与代谢性疾病

阮雄中^1,*, 管又飞²

¹重庆医科大学脂质研究中心，脂糖代谢性疾病重庆市重点实验室，重庆 400016；²大连医科大学医学科学研究院，大连 116044

摘要

近年来，我国在糖脂代谢前沿基础研究、应用转化研发和代谢性疾病临床研究等方面已取得若干重大进展，解析了六个代谢领域基础前沿的重大科学问题，包括肠道微生物组学与脂代谢、细胞应激和蛋白稳态、营养感知与信号传导、代谢组学、脂肪组织生物学与肥胖以及免疫代谢等。在代谢病发病机制研究方面，我国学者在非酒精性脂肪肝病、糖尿病、肿瘤和衰老发生、发展及防治中的作用及新药物靶点的确立和新药筛选方面也取得了很好的成绩 。本专栏特邀了多位在糖脂代谢稳态调节和代谢病研究领域著名的专家和青年学者，介绍了糖脂代谢稳态的一些热点问题和研究成果，包括7篇综述和6篇研究论文。

Regulation of lipids and glucose metabolism homeostasis and metabolic diseases

RUAN Xiong-Zhong^1,*, GUAN You-Fei²

¹Chongqing Key Laboratory of Lipid and Glucose Metabolism, Centre for Lipid Research, Chongqing Medical University, Chongqing 400016, China；²Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China

Abstract

In recent years, our country has made major progress in the basic research of lipids and glucose metabolism, as well as clinical research of metabolic disease. Our country has analyzed the basic frontier of six major scientific problems, including intestinal microbiome and lipid metabolism, cell stress and protein homeostasis, nutrition perception and signaling, metabolomics, adipose tissue biology and obesity and immune metabolism, etc. In terms of the pathogenesis of metabolic diseases, Chinese scholars have also made great achievements in the occurrence, development, prevention and treatment of non-alcoholic fatty liver disease, diabetes, tumor and aging, the establishment of new drug targets and the screening of new drugs. This special topic invited a number of famous experts and young scholars in the study of glucose and lipid metabolism regulation and metabolic diseases to introduce some hot issues and research achievements of lipids and glucose metabolism homeostasis, including 7 reviews and 6 original articles.

收稿日期：　　录用日期：

通讯作者：阮雄中　　E-mail: xiongzruan@foxmail.com

DOI: 10.13294/j.aps.2021.0077

引用本文：

阮雄中, 管又飞. 糖脂代谢稳态调节与代谢性疾病[J]. 生理学报 2021; 73 (5): 691-693.

RUAN Xiong-Zhong, GUAN You-Fei. Regulation of lipids and glucose metabolism homeostasis and metabolic diseases. Acta Physiol Sin 2021; 73 (5): 691-693 (in Chinese with English abstract).