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针刺对偏头痛治疗机制的神经影像学研究现状

刘路¹, 田甜¹, 徐韬¹, 王亚楠¹, 倪夕秀¹, 李晓¹, 何振曦¹, 高山¹, 梁繁荣^1,2, 赵凌^1,2,*

¹成都中医药大学针灸推拿学院，成都 610075；²四川省针灸与时间生物学重点实验室，成都 610075

摘要

偏头痛是以中重度头痛及各种神经症状为特征的神经系统疾病。针刺作为常用的非药物疗法，在偏头痛防治方面具有疗效佳、副作用少的优势，但其作用机制尚不明确。近年来，神经影像学技术的进步有助于客观评估针刺治疗偏头痛的疗效，并为探索针刺治疗偏头痛的中枢机制提供了机会。本文从针刺治疗偏头痛急性发作和针刺预防偏头痛发作的中枢机制两个方面对近10年来针刺治疗偏头痛的神经影像学研究进行综述，以期更好地了解针刺对偏头痛治疗机制的神经影像学研究现状，为今后研究提供切入点。

关键词： 针刺; 无先兆偏头痛; 功能神经影像

分类号：R2;R277;R277.7

Revealing the mechanisms underlying the therapeutic effects of acupuncture on migraine using neuroimaging: a narrative review

LIU Lu¹, TIAN Tian¹, XU Tao¹, WANG Ya-Nan¹, NI Xi-Xiu¹, LI Xiao¹, HE Zhen-Xi ¹, GAO Shan¹, LIANG Fan-Rong^1,2, ZHAO Ling^1,2,*

¹Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China；²Acupuncture & Chronobiology Key Laboratory of Sichuan Province, Chengdu 610075, China

Abstract

Migraine is a neurological disorder characterized by attacks of moderate or severe headache and various neurological symptoms. Acupuncture, as a commonly used non-pharmacological therapy, has the advantage of obvious therapeutic effect and few side effects in the prevention and treatment of migraine. But the underlying mechanism of acupuncture on migraine remains unclear. Recently, advances in neuroimaging technology have helped to objectively assess the effect of acupuncture on treating migraine and offered new opportunities to explore the central mechanism of acupuncture on treating migraine. In order to better understand the current status of neuroimaging studies on the therapeutic mechanism of acupuncture on migraine and shed light on future research, this review aims to overview the neuroimaging studies in recent 10 years from two aspects: (1) Central mechanism of acupuncture on treating acute migraine attack; (2) Central mechanism of acupuncture on preventing migraine attack.

Key words: Acupuncture; migraine without aura; functional neuroimaging

收稿日期：2021-01-17　　录用日期：2021-05-26

通讯作者：赵凌　　E-mail: zhaoling@cdutcm.edu.cn

DOI: 10.13294/j.aps.2021.0042

引用本文：

刘路, 田甜, 徐韬, 王亚楠, 倪夕秀, 李晓, 何振曦, 高山, 梁繁荣, 赵凌. 针刺对偏头痛治疗机制的神经影像学研究现状[J]. 生理学报 2021; 73 (3): 433-445.

LIU Lu, TIAN Tian, XU Tao, WANG Ya-Nan, NI Xi-Xiu, LI Xiao, HE Zhen-Xi , GAO Shan, LIANG Fan-Rong, ZHAO Ling. Revealing the mechanisms underlying the therapeutic effects of acupuncture on migraine using neuroimaging: a narrative review. Acta Physiol Sin 2021; 73 (3): 433-445 (in Chinese with English abstract).