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Rab蛋白在神经退行性疾病中作用的研究进展

李云, 王雪, 谢俊霞, 宋宁^*

青岛大学基础医学院生理学与病理生理学系，脑科学与疾病研究院，青岛 266071

摘要

Rab蛋白是Ras超家族成员，是一类小分子GTP结合蛋白。在大分子物质进入细胞的内吞途径和细胞器间的物质转运过程中，Rab蛋白通过招募其效应蛋白可作用于囊泡形成、转运、黏附和融合，是囊泡运输过程中的关键调节因素。Rab蛋白及其效应蛋白定位和功能的改变与多种疾病相关。本文就Rab蛋白的主要功能及其在帕金森病、阿尔茨海默病、亨廷顿病等神经退行性疾病发生与发展过程中的作用进行综述。

关键词： Rab蛋白; 神经退行性疾病; α-突触核蛋白; β-淀粉样蛋白; Tau蛋白; 亨廷顿蛋白

分类号：R338;Q42;R741

Research progress of Rab proteins in neurodegenerative diseases

LI Yun, WANG Xue, XIE Jun-Xia, SONG Ning^*

Department of Physiology and Pathophysiology, School of Basic Medicine; Institute of Brain Science and Disease, Qingdao University, Qingdao 266071, China

Abstract

As a member of the Ras superfamily, Rab proteins are small GTP-binding proteins. In the process of endocytosis of macromolecules and substances delivery between organelles, Rab proteins act on vesicle formation, transport, tethering and fusion by recruiting their effectors, therefore being key regulatory factors in vesicle trafficking. Disturbance of localizations and functions of Rab proteins and their effectors are involved in the pathogenesis of several diseases. This review focuses on the main functions of Rab proteins and their possible roles in the onset and progression of neurodegenerative diseases including Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease.

Key words: Rab proteins; neurodegenerative diseases; α-synuclein; amyloid β-protein; Tau; Huntington protein

收稿日期：2020-06-11　　录用日期：2020-11-04

通讯作者：宋宁　　E-mail: ningsong@qdu.edu.cn

DOI: 10.13294/j.aps.2021.0009

引用本文：

李云, 王雪, 谢俊霞, 宋宁. Rab蛋白在神经退行性疾病中作用的研究进展[J]. 生理学报 2021; 73 (2): 315-328.

LI Yun, WANG Xue, XIE Jun-Xia, SONG Ning. Research progress of Rab proteins in neurodegenerative diseases. Acta Physiol Sin 2021; 73 (2): 315-328 (in Chinese with English abstract).