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光纤记录系统在神经科学研究中的应用

张莉唯¹, 毕爱玲^2,3, 李谦¹, 毕宏生^2,3,*

¹山东中医药大学眼科与视光医学院，济南 250014；²山东中医药大学附属眼科医院，济南 250002；³山东中医药大学眼科研究所，山东省中西医结合眼病防治重点实验室，山东省高校中西医结合眼病防治技术(强化)重点实验室，济南 250002

摘要

近年来，光纤记录系统作为一种记录自由活动动物大脑特定核团神经元活动的技术，在神经科学领域研究中广受欢迎，是研究动物神经元活动与行为关系的重要技术手段。本文综述了单通道光纤记录系统、多通道光纤记录系统及多色光纤记录系统在认知、行为学、心理学等神经科学基础及神经疾病中的应用，并简述了光纤记录系统与功能磁共振成像技术结合、光纤记录系统与递质探针结合在神经科学领域中的应用。

关键词： 光纤记录系统; 单通道、多通道、多色光纤记录系统; 神经科学; 神经疾病

分类号：R319

Application of fiber photometry in neuroscience research

ZHANG Li-Wei¹, BI Ai-Ling^2,3, LI Qian¹, BI Hong-Sheng^2,3,*

¹Shandong University of Traditional Chinese Medicine Medical College of Optometry and Ophthalmology, Jinan 250014, China；²ffiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250002, China；³Eye Institute of Shandong University of Traditional Chinese Medicine, Shandong Province Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Disease, Key Laboratory of Integrative Medicine for Prevention and Treatment of Ocular Diseases in Colleges and Universities of Shandong Province, Jinan 250002, China

Abstract

 In recent years, fiber photometry has been widely used in the field of neuroscience as an important technique for recording the activity of neurons in the specific nuclei of freely moving animal. This review summarized the application of single-channel, multi-channel, and multi-color fiber photometry techniques in the neuroscience research of cognition, behavior, psychology and neurological diseases. In addition, it briefly introduced the applications of fiber photometry combined with functional magnetic resonance imaging technology, and fiber photometry combined with probe technology in the neuroscience research.

Key words: fiber photometry; single-channel, multi-channel, multi-color fiber photometry; neuroscience; neurological disease

收稿日期：2020-07-03　　录用日期：2020-12-10

通讯作者：毕宏生　　E-mail: hongshengbi1@163.com

DOI: 10.13294/j.aps.2021.0013

引用本文：

张莉唯, 毕爱玲, 李谦, 毕宏生. 光纤记录系统在神经科学研究中的应用[J]. 生理学报 2021; 73 (2): 306-314.

ZHANG Li-Wei, BI Ai-Ling, LI Qian, BI Hong-Sheng. Application of fiber photometry in neuroscience research. Acta Physiol Sin 2021; 73 (2): 306-314 (in Chinese with English abstract).