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皮层5-羟色胺受体亚基3A阳性抑制性神经元：类型及功能的多样性

吴锦云¹, 刘宏志¹, 齐妍清¹, 吴晓阳¹, 陈扬¹, 吕江腾², 龚玲¹, 何苗^1,*

¹复旦大学脑科学研究院，上海 200032；²上海交通大学基础医学院，上海 200025

摘要

大脑皮层中存在三大类γ-氨基丁酸(γ-aminobutyric acid, GABA)能抑制性神经元，分别表达小清蛋白(parvalbumin, PV)、生长抑素(somatostatin, SOM)和5-羟色胺受体亚基3A (5-hydroxytryptamine receptor 3A, Htr3a)。其中Htr3a阳性(Htr3a+)神经元主要起源于尾侧神经节隆起(caudal ganglionic eminence, CGE)，包含基因表达、形态、电生理特性和环路连接等方面高度异质的多种亚型。本文从以上各方面对Htr3a+神经元的特性及其环路功能进行总结，并介绍现有的研究Htr3a+神经元常用的小鼠工具。

关键词： 5-羟色胺受体亚基3A; GABA能抑制性神经元; 神经元异质性

分类号：Q189

Cortical 5-hydroxytryptamine receptor 3A (Htr3a) positive inhibitory neurons: diversity in type and function

WU Jin-Yun¹, LIU Hong-Zhi¹, QI Yan-Qing¹, WU Xiao-Yang¹, CHEN Yang¹, LYU Jiang-Ten², GONG Ling¹, HE Miao^1,*

¹Institutes of Brain Science, Fudan University, Shanghai 200032, China；²Shanghai Jiao Tong University College of Basic Medical Sciences, Shanghai 200025, China

Abstract

Cortical GABAergic inhibitory neurons are composed of three major classes, each expressing parvalbumin (PV), somatostatin (SOM) and 5-hydroxytryptamine receptor 3A (Htr3a), respectively. Htr3a+ inhibitory neurons are mainly derived from the caudal ganglionic eminence (CGE). This highly heterogeneous group of inhibitory neurons are comprised of many different subtypes with distinct molecular signatures, morphological and electrophysiological properties and connectivity patterns. In this review, we summarized recent research progress regarding cortical Htr3a+ inhibitory neurons, focusing on their molecular, morphological and electrophysiological diversity, and introduced some genetic mouse tools that were used to study Htr3a+ inhibitory neurons.

Key words: 5-hydroxytryptamine receptor 3A; GABAergic inhibitory neuron; neuron heterogeneity

收稿日期：2020-07-16　　录用日期：2020-12-10

通讯作者：何苗　　E-mail: hem@fudan.edu.cn

DOI: 10.13294/j.aps.2021.0012

引用本文：

吴锦云, 刘宏志, 齐妍清, 吴晓阳, 陈扬, 吕江腾, 龚玲, 何苗. 皮层5-羟色胺受体亚基3A阳性抑制性神经元：类型及功能的多样性[J]. 生理学报 2021; 73 (2): 295-305.

WU Jin-Yun, LIU Hong-Zhi, QI Yan-Qing, WU Xiao-Yang, CHEN Yang, LYU Jiang-Ten, GONG Ling, HE Miao. Cortical 5-hydroxytryptamine receptor 3A (Htr3a) positive inhibitory neurons: diversity in type and function. Acta Physiol Sin 2021; 73 (2): 295-305 (in Chinese with English abstract).