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平滑肌22α蛋白在血管稳态和血管重构中的作用

张宁, 窦永青, 韩梅

河北医科大学基础医学院，石家庄 050017

摘要

有关血管稳态和重构的分子机制一直是近年来的研究热点，也被视为治疗血管损伤性疾病的突破点。大量研究证实，血管损伤修复及病理性重构过程与血管平滑肌细胞(vascular smooth muscle cells, VSMCs)的表型转化、异常增殖与迁移、细胞衰老关系密切。平滑肌22α (smooth muscle 22α, SM22α)蛋白是一种在收缩型VSMCs中大量表达的细胞骨架相关蛋白，可通过与F-actin相互作用促进应力纤维形成，维持VSMCs收缩性，还可作为信号调节分子参与血管稳态和重构。本文综述了近年SM22α在血管稳态和血管重构中作用的研究进展。

关键词： 平滑肌22α蛋白; 血管损伤; 血管平滑肌细胞

分类号：R310;R310.11

Roles of smooth muscle 22α in vascular homeostasis and vascular remodeling

ZHANG Ning, DOU Yong-Qing, HAN Mei

College of Basic Medical Sciences, Hebei Medical University, Shijiazhuang 050017, China

Abstract

The research on the molecular mechanism of vascular injury has been a hot topic in recent years since the mechanism can be targeted for the treatment of vascular injury diseases. A large number of studies have found that vascular injury, repair and pathological remodeling are closely related to phenotype switching, abnormal proliferation and migration, and apoptosis of vascular smooth muscle cells (VSMCs). Smooth muscle 22α (SM22α) is a shape change and transformation sensitive F-actin-binding protein. SM22α decorates the contractile filament bundles within cultured VSMCs exhibiting differentiated phenotypes. In addition, SM22α is involved in regulation of cell signaling pathways related to vascular homeostasis and vascular remodeling. Here, we reviewed the recent research progress of SM22α in vascular homeostasis and remodeling.

Key words: smooth muscle 22α; vascular injury; vascular smooth muscle cells

收稿日期：2020-03-30　　录用日期：2020-05-19

通讯作者：　　E-mail:

DOI: 10.13294/j.aps.2021.0004

引用本文：

张宁, 窦永青, 韩梅. 平滑肌22α蛋白在血管稳态和血管重构中的作用[J]. 生理学报 2021; 73 (1): 82-88.

ZHANG Ning, DOU Yong-Qing, HAN Mei. Roles of smooth muscle 22α in vascular homeostasis and vascular remodeling. Acta Physiol Sin 2021; 73 (1): 82-88 (in Chinese with English abstract).