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非编码RNA参与调控哮喘T细胞功能的研究进展

黄振利, 熊维宁^*

华中科技大学同济医学院附属同济医院呼吸与危重症医学科，卫生部呼吸系统疾病重点实验室，武汉 430030

摘要

支气管哮喘(简称哮喘)是一种以气道炎性反应、高反应性及气道重塑为特征的慢性炎症性疾病，T细胞在其中发挥着至关重要的作用。非编码RNA (non-coding RNA, ncRNA)是转录组中不编码蛋白质的RNA分子，主要包括微小RNA (microRNA, miRNA)、长链非编码RNA (long non-coding RNA, lncRNA)、环状RNA (circular RNA, circRNA)等，广泛存在于真核生物基因组中，参与调控多种生物学过程。已有研究表明，ncRNA在哮喘T细胞的活化及转换等过程中起着重要作用，其具体作用机制及临床应用值得深入探讨。本文综合分析了近年来miRNA、lncRNA和circRNA在哮喘T细胞功能调控中的研究进展，为更好地理解哮喘发病机制和提高诊断水平提供新思路，同时也为利用ncRNA的调节潜能开发治疗策略提供理论依据。

关键词： 非编码RNA; 环状RNA; 长链非编码RNA; 微小RNA; 哮喘; T细胞

分类号：R392.1; R4

Research progress of non-coding RNA in regulating the function of T cells in asthma

HUANG Zhen-Li, XIONG Wei-Ning^*

Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

Abstract

Bronchial asthma (i.e. asthma) is a chronic inflammatory disease characterized by airway inflammatory response, hyperresponsiveness and airway remodeling, in which T cells play a vital role, especially T helper cells (Th cells). Non-coding RNAs (ncRNAs) are the RNAs that do not encode proteins, mainly including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), which are widely found in eukaryotic genomes and participate in the regulation of various biological processes. Previous studies have shown that ncRNAs play an important role in the activation and transformation of T cells and other biological processes in asthma. The specific molecular mechanism and clinical application are worth in-depth discussion. This article reviewed the research progress in regulation of miRNAs, lncRNAs and circRNAs on T cells in asthma in recent years.

Key words: non-coding RNAs; circular RNA; long non-coding RNA; microRNA; asthma; T cells

收稿日期：2020-04-02　　录用日期：2020-08-17

通讯作者：熊维宁　　E-mail: xiongdoctor@qq.com

DOI: 10.13294/j.aps.2020.0056

引用本文：

黄振利, 熊维宁. 非编码RNA参与调控哮喘T细胞功能的研究进展[J]. 生理学报 2020; 72 (5): 586-596.

HUANG Zhen-Li, XIONG Wei-Ning. Research progress of non-coding RNA in regulating the function of T cells in asthma. Acta Physiol Sin 2020; 72 (5): 586-596 (in Chinese with English abstract).