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铁死亡中的代谢调控网络及其与肺相关疾病的联系

成海鹏¹, 冯丹丹¹, 岳少杰², 罗自强^1,*

¹中南大学湘雅医学院生理学系，长沙 410078；²中南大学湘雅医院儿科，长沙 410078

摘要

铁死亡(ferroptosis)是新近发现的一种铁依赖性的脂质过氧化驱动的非凋亡形式的调节性细胞死亡方式。目前的研究表明，铁死亡会影响体内许多代谢过程和稳态平衡，并且它与许多肺疾病有关，包括急性肺损伤、慢性阻塞性肺疾病和肺纤维化等。目前，关于铁死亡的研究尚处于起始阶段，现有研究已确认铁死亡受多种基因调控，主要涉及铁稳态和脂质过氧化代谢等方面的基因改变，且机制复杂。本综述基于先前的研究，总结了部分与铁死亡有关的代谢调控网络，并讨论了铁死亡在诸多肺相关疾病病理生理学过程中的作用，期望为此类疾病的研究和治疗提供新的思路和借鉴。

关键词： 铁死亡; 代谢网络; 急性肺损伤; 慢性阻塞性肺疾病; 肺纤维化

分类号：R363

The metabolic networks of ferroptosis and links to lung diseases

CHENG Hai-Peng¹, FENG Dan-Dan¹, YUE Shao-Jie², LUO Zi-Qiang^1,*

¹Department of Physiology, Xiangya School of Medicine, Central South University, Changsha 410078, China；²Department of Pediatrics, Xiangya Hospital, Central South University, Changsha 410078, China

Abstract

Ferroptosis is a newly discovered non-apoptotic form of regulated cell death driven by iron-dependent lipid peroxidation. The present studies have shown that many metabolic processes and homeostasis are affected by ferroptosis. It is related to many lung diseases, including acute lung injury, chronic obstructive pulmonary disease and pulmonary fibrosis, etc. Currently, the research on ferroptosis is still in its infancy. Previous studies have confirmed that ferroptosis is regulated by a variety of genes, and the mechanism is complex, mainly involving iron homeostasis and lipid peroxidation metabolism. This review summarizes some regulation networks of metabolic processes associated with ferroptosis and discusses the roles of ferroptosis in the pathophysiological progression of many lung diseases. We expected to provide new ideas and references for the treatment of these diseases.

Key words: ferroptosis; metabolic networks; acute lung injury; chronic obstructive pulmonary disease; pulmonary fibrosis

收稿日期：2020-05-21　　录用日期：2020-08-17

通讯作者：罗自强　　E-mail: luoziqiang@csu.edu.cn

DOI: 10.13294/j.aps.2020.0069

引用本文：

成海鹏, 冯丹丹, 岳少杰, 罗自强. 铁死亡中的代谢调控网络及其与肺相关疾病的联系[J]. 生理学报 2020; 72 (5): 566-574.

CHENG Hai-Peng, FENG Dan-Dan, YUE Shao-Jie, LUO Zi-Qiang. The metabolic networks of ferroptosis and links to lung diseases. Acta Physiol Sin 2020; 72 (5): 566-574 (in Chinese with English abstract).