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降钙素基因相关肽在突触可塑性调控和情绪记忆中的作用

武鑫, 王冬慧, 高剑峰^*

河南中医药大学基础医学院，郑州 450046

摘要

降钙素基因相关肽(calcitonin gene-related peptide, CGRP)是由降钙素基因表达的一种神经肽类物质，分为α和β两种亚型。CGRP在人体内广泛分布，在外周和中枢神经系统中高表达。研究表明CGRP参与多种生理和病理生理活动，包括伤害性感觉信号的形成与传导、心血管功能的调节作用等。近年来越来越多的研究表明，在中枢神经系统中CGRP参与突触可塑性调控，并与认知和学习记忆功能密切相关。本文综述了CGRP在突触可塑性调控和情绪记忆中的作用研究进展，以期为临床治疗相关神经系统疾病提供新的分子靶点和理论依据。

关键词： 降钙素基因相关肽; 认知; 情绪记忆; 突触可塑性; 谷氨酸受体

分类号：R338.64

Role of calcitonin gene-related peptide in regulation of synaptic plasticity and process of the emotional memory

WU Xin, WANG Dong-Hui, GAO Jian-Feng^*

School of Basic Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China

Abstract

Calcitonin gene-related peptide (CGRP) is a neuropeptide coded by the calcitonin gene and divided into α and β subtypes. CGRP is widely distributed throughout the human body and highly expressed in the peripheral and central nervous system. Studies have shown that CGRP plays a role in a variety of physiological and pathophysiological activities, such as the formation and transmission of nociceptive signal, as well as the regulation of cardiovascular function. Recently, more and more researches have shown that CGRP is involved in the regulation of synaptic plasticity, cognitive function and learning memory in the central nervous system. This paper reviews the role of CGRP in regulation of synaptic plasticity and process of emotional memory, hoping to provide a new molecular target and theoretical basis for clinical treatment of neurological diseases.

Key words: Calcitonin gene-related peptide; cognition; emotional memory; synaptic plasticity; glutamate receptor

收稿日期：2019-03-21　　录用日期：2019-07-03

通讯作者：高剑峰　　E-mail: jc.gjfeng@hotmail.com

DOI: 10.13294/j.aps.2019.0067

引用本文：

武鑫, 王冬慧, 高剑峰. 降钙素基因相关肽在突触可塑性调控和情绪记忆中的作用[J]. 生理学报 2020; 72 (3): 399-406.

WU Xin, WANG Dong-Hui, GAO Jian-Feng. Role of calcitonin gene-related peptide in regulation of synaptic plasticity and process of the emotional memory. Acta Physiol Sin 2020; 72 (3): 399-406 (in Chinese with English abstract).