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组蛋白3甲基转移酶MLL4的研究进展

郭慧慧¹, 卢圣锋², 蔡云¹, 刘淑宝², 朱冰梅^2,*

¹南京中医药大学针药结合教育部重点实验室，南京 210023；²四川大学华西医院再生医学研究中心，成都 610041

摘要

混合连锁白血病因子4 (mixed lineage leukemia 4, MLL4)是组蛋白H3第4位赖氨酸(H3K4)一种特异的甲基化转移酶，也是COMPASS/Set1-like蛋白复合物中重要成员之一。MLL4蛋白本身及其介导的H3K4甲基化修饰，均能引起染色质结构和功能的改变，调控基因转录与表达。随着近年对MLL4蛋白研究的深入，MLL4基因、MLL4蛋白、蛋白复合物在各组织器官的发育、肿瘤疾病等生理与病理生理过程中的作用逐渐被揭示。本文对MLL4基因、MLL4蛋白特征、生物学功能及其对疾病的影响等方面的研究进展进行综述，以期进一步理解组蛋白甲基化转移酶对基因表达调控的影响及其非酶学依赖的功能，为相关疾病预防和诊治提供新的思路。

关键词： MLL4; 组蛋白3赖氨酸4; 组蛋白甲基化; 组蛋白甲基化转移酶

分类号：R34

Research progress of histone 3 methyltransferase MLL4

GUO Hui-Hui¹, LU Sheng-Feng², CAI Yun¹, LIU Shu-Bao², ZHU Bing-Mei^2,*

¹Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China；²Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, China

Abstract

Mixed linked leukemia 4 (MLL4) is a specific methyltransferase of histone 3 position lysine 4 (H3K4). It is also one of the important members of COMPASS/Set1-like protein complex. Both MLL4 protein itself and its mediated H3K4 methylation modification can cause changes in chromatin structure and function, thus regulating gene transcription and expression. With the studies of MLL4 protein in recent years, the roles of MLL4 gene, MLL4 protein and protein complex in the development of tissues and organs, tumor diseases and other physiological and pathophysiological processes have been gradually revealed. In this paper, the research progress of MLL4 gene, MLL4 protein characteristics, biological function and its effect on disease were reviewed, in order to further understand the effect of histone methyltransferase on gene expression regulation, as well as its non-enzyme dependent function. This paper may provide new ideas for the prevention, diagnosis and treatment of related diseases.

Key words: MLL4; H3K4; histone methylation; histone methyltransferase

收稿日期：2018-12-25　　录用日期：2019-03-06

通讯作者：朱冰梅　　E-mail: zhubm64@hotmail.com

DOI: 10.13294/j.aps.2019.0051

引用本文：

郭慧慧, 卢圣锋, 蔡云, 刘淑宝, 朱冰梅. 组蛋白3甲基转移酶MLL4的研究进展[J]. 生理学报 2019; 71 (4): 637-644.

GUO Hui-Hui, LU Sheng-Feng, CAI Yun, LIU Shu-Bao, ZHU Bing-Mei. Research progress of histone 3 methyltransferase MLL4. Acta Physiol Sin 2019; 71 (4): 637-644 (in Chinese with English abstract).