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远距离细胞连接——膜纳米管的生物功能

沈静, 张幼怡, 肖晗^*

北京大学第三医院心内科血管医学研究所，国家卫生健康委员会心血管分子生物学与调节肽重点实验室，分子心血管学教育部重点实验室，心血管受体研究北京市重点实验室，北京 100191

摘要

细胞连接为细胞间信号交流提供了直接通道，在机体的生理病理过程中发挥重要作用。膜纳米管是普遍存在于细胞间的远距离连接结构，不仅可远距离传输多种信号分子，也可传输线粒体，还与缝隙连接等细胞连接协同传输信号。近年来，膜纳米管的研究受到越来越多的关注，关于膜纳米管与其他细胞间信号传递方式的异同及其生物学功能，也有不少研究进展。本文主要综述了近年关于膜纳米管形态结构的多样性、与其他信号传递方式的异同以及其生理和病理功能等方面的研究进展。

关键词： 膜纳米管; 细胞间通讯; 信号传递; 生物功能

分类号：Q249; R34

The biological functions of cell-to-cell connection over long distance--membrane nanotube

SHEN Jing, ZHANG You-Yi, XIAO Han^*

Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China

Abstract

Cell-to-cell connections provide conduits for signal exchanges, and play important functional roles in physiological and pathological processes of multicellular organisms. Membrane nanotubes are common long-distance connections between cells, not only transfer molecule signals and mitochondria, but also cooperate with gap junction and other cell-to-cell communications to transfer signals. During the last decade, there are many studies about membrane nanotubes, which focus on the similarities and differences between membrane nanotubes and other cell-to-cell communications, as well as their biological functions. In the present review, we summarized the latest findings about the structural diversity, the similarities and differences in signal transmission with other types of cell-to-cell communications, and physiological and pathological roles of membrane nanotubes.

Key words: membrane nanotube; cell-to-cell communication; signal transduction; biological function

收稿日期：2018-07-18　　录用日期：2018-12-18

通讯作者：肖晗　　E-mail: xiaohan@bjmu.edu.cn

DOI: 10.13294/j.aps.2019.0020

引用本文：

沈静, 张幼怡, 肖晗. 远距离细胞连接——膜纳米管的生物功能[J]. 生理学报 2019; 71 (2): 196-204.

SHEN Jing, ZHANG You-Yi, XIAO Han. The biological functions of cell-to-cell connection over long distance--membrane nanotube. Acta Physiol Sin 2019; 71 (2): 196-204 (in Chinese with English abstract).