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高同型半胱氨酸促进肾脏疾病的发生与发展

周云枫¹, 管又飞^2,*

¹深圳大学医学部医学中心，基础医学院生理系，深圳 518060；²大连医科大学医学科学研究院，大连 116044

摘要

同型半胱氨酸是蛋氨酸代谢的中间产物，其代谢异常导致血中同型半胱氨酸浓度高于16 μmol/L，称为高同型半胱氨酸血症。目前研究表明，高同型半胱氨酸血症不仅与心脑血管疾病、外周血管病变、神经系统退行性疾病、糖尿病、妊娠高血压综合征、肝硬化等疾病的发病密切相关，而且在肾脏疾病的发生、发展过程中发挥重要作用。本文将就高同型半胱氨酸血症与肾脏疾病的关系作一综述，进一步明确其在肾脏疾病发生和发展中的重要性，将可能为肾脏疾病的防治提供新的线索。   

关键词： 同型半胱氨酸; 高同型半胱氨酸血症; 肾脏疾病

分类号：R333.6

Hyperhomocysteinemia and kidney diseases

ZHOU Yun-Feng¹, GUAN You-Fei^2,*

¹Medical Research Center, Physiology Department of Basic Medical College, Shenzhen University Health Science Center, Shenzhen 518060, China；²Advanced Institute of Medical Sciences, Dalian Medical University, Dalian 116044, China

Abstract

Homocysteine (Hcy) is an intermediate metabolite of methionine metabolism. Hyperhomocysteinemia (HHcy) is defined as a condition characterized by plasma Hcy level above 16 μmol/L which can result from abnormal Hcy metabolism. HHcy has been confirmed to be related to cardio-cerebrovascular disease, peripheral vascular disorders, neurodegenerative diseases, diabetes, pregnancy-induced hypertension syndrome, liver cirrhosis and kidney diseases. In this review, we summarize the correlation between HHcy and kidney diseases. Elucidating the role of HHcy in kidney diseases may provide a new strategy to prevent and treat kidney diseases.

Key words: Homocysteine; hyperhomocysteinemia; kidney diseases

收稿日期：2018-08-09　　录用日期：2018-11-12

通讯作者：管又飞　　E-mail: guanyf@dmu.edu.cn

DOI: 10.13294/j.aps.2018.0087

引用本文：

周云枫, 管又飞. 高同型半胱氨酸促进肾脏疾病的发生与发展[J]. 生理学报 2018; 70 (6): 607-611.

ZHOU Yun-Feng, GUAN You-Fei. Hyperhomocysteinemia and kidney diseases. Acta Physiol Sin 2018; 70 (6): 607-611 (in Chinese with English abstract).