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复杂疾病的离子组学研究进展

应慧敏¹, 张焱^2,*

¹杭州市西溪医院内分泌科，杭州 310023；²深圳大学生命与海洋科学学院，深圳 518071

摘要

离子组学是一个研究特定生物系统中各种元素的组成、分布以及它们在不同生理、病理条件下发生变化的新兴交叉学科。它结合了高通量元素谱检测技术和生物信息学方法，为在系统水平上深入认识这些元素的生物学利用过程与功能提供了重要新思路。越来越多的研究结果表明，离子组学在复杂疾病的病因学研究、早期诊断与筛查和治疗措施制定等方面具有重要的理论与实用价值。本文着重介绍了当前离子组学在一些复杂疾病研究领域取得的新进展，有助于我们进一步探索不同元素及其所构成的动态离子网络对疾病发生与发展的影响和相关重要属性。

关键词： 离子组; 微量元素; 复杂疾病; 生物信息学; 网络

分类号：Q493.7;R363;O614

Progress on ionomics of complex diseases

YING Hui-Min¹, ZHANG Yan^2,*

¹Department of Endocrinology, Hangzhou Xixi Hospital, Hangzhou 310023, China；²College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518071, China

Abstract

Ionomics is a new multidisciplinary scientific field for investigating the composition and distribution of all chemical elements in specific biological systems as well as their variations under different physiological and pathological conditions. It combines both high-throughput techniques for element profile measurement and bioinformatic methods, which provides new ideas for obtaining a systems-level understanding of biological utilization and functions of these elements. More and more results of researches suggest that ionomics has important theoretical and practical values in etiological study, early diagnosis and screening, and therapeutic strategy selection for complex diseases. In this review, we focus on current advances in the ionomic studies of several complex diseases, which may help further understand the effect and important properties of individual elements, as well as their dynamic ionomic networks in the occurrence and development of diseases.

Key words: ionome; ionomics; trace element; complex disease; network

收稿日期：2017-12-15　　录用日期：2018-05-03

通讯作者：张焱　　E-mail: zhangyan@szu.edu.cn

DOI: 10.13294/j.aps.2018.0036

引用本文：

应慧敏, 张焱. 复杂疾病的离子组学研究进展[J]. 生理学报 2018; 70 (4): 413-423.

YING Hui-Min, ZHANG Yan. Progress on ionomics of complex diseases. Acta Physiol Sin 2018; 70 (4): 413-423 (in Chinese with English abstract).