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补体C1q/肿瘤坏死因子相关蛋白家族对心血管代谢紊乱及相关危险因素调控的研究进展

张诗晗¹, 杜芸辉², 于海存¹, 李玉明^3,*, 刘慧荣¹

¹首都医科大学基础医学院生理学与病理生理学系，北京 100069；²首都医科大学附属安贞医院-北京心肺血管疾病研究所，北京 100029；³燕京医学院基础医学院，北京 101300

摘要

补体C1q/肿瘤坏死因子相关蛋白(complement C1q/TNF related protein, CTRP)是新近发现的一类脂肪因子超家族，目前已经发现该家族有15个成员。CTRP家族成员结构均包含一个氨基末端的信号肽、一个短的可变结构域、一个胶原样结构域和一个羧基末端的球形结构域，其结构与脂联素有高度同源性，每个成员都有其独特的组织表达和多样化的功能。本文将对CTRP家族各成员的组织分布和对心血管代谢紊乱及相关危险因素如糖脂代谢异常、糖尿病的调控作一综述。

关键词： C1q/肿瘤坏死因子相关蛋白; 表达; 功能; 疾病

分类号：R363.2+1

Research advances in the regulation of cardiovascular metabolic disorders and its related risk factors by C1q/TNF related proteins

ZHANG Shi-Han¹, DU Yun-Hui², YU Hai-Cun¹, LI Yu-Ming^3,*, LIU Hui-Rong¹

¹Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China；²Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China；³Department of Basic Medical Sciences, Yanjing Medical College, Capital Medical University, Beijing 101300, China

Abstract

The complement C1q/TNF related protein (CTRP) family is rapidly growing and currently comprises 15 members. Although CTRP proteins share a common structure composed of four distinct domains: a signal peptide at the N terminus, a short variable region, a collagenous domain, and a C-terminal globular domain, which is homologous to adiponectin, each CTRP has a unique tissue expression profile and varied function. In this review we focus on the biochemistry and pleiotropic functions of CTRPs as new molecular mediators regulating cardiovascular metabolic disorders and its related risk factors diseases.

Key words: complement C1q/TNF related protein; expression; function; disease

收稿日期：2017-09-12　　录用日期：2017-11-02

通讯作者：李玉明　　E-mail: ymlea@sina.com

DOI: 10.13294/j.aps.2018.0014

引用本文：

张诗晗, 杜芸辉, 于海存, 李玉明, 刘慧荣. 补体C1q/肿瘤坏死因子相关蛋白家族对心血管代谢紊乱及相关危险因素调控的研究进展[J]. 生理学报 2018; 70 (3): 310-318.

ZHANG Shi-Han, DU Yun-Hui, YU Hai-Cun, LI Yu-Ming, LIU Hui-Rong. Research advances in the regulation of cardiovascular metabolic disorders and its related risk factors by C1q/TNF related proteins. Acta Physiol Sin 2018; 70 (3): 310-318 (in Chinese with English abstract).