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心理痛与生理痛的共享神经机制

于文军^1,2, 江锦祥¹, 杨莉^1,*

¹华南师范大学心理学院，广州 510631；²井冈山大学教育学院，吉安 343009

摘要

根据刺激源、感觉通道等方面的差异可以将疼痛区分为心理痛和生理痛。大量研究显示心理痛与生理痛存在某些相同的神经生物学基础，共享某些疼痛神经回路，特别是背侧前扣带回和前脑岛等脑区在心理痛和生理痛中都发挥着重要作用。心理痛与生理痛之间既有共性又有差异而且相互影响。因此，探寻心理痛与生理痛脑神经机制的重叠与分离的研究，不仅为揭示两种疼痛之间的关系而且为探讨干预心理痛的靶点带来契机。本文立足于心理痛和生理痛人类和动物实验研究进展，系统归纳了两种疼痛间的共性、差异和相互作用。深入探究心理痛与生理痛脑神经机制重叠的边界条件，以及慢性心理痛是否也出现了类似生理痛一样的大脑皮质结构的可塑性改变将成为未来研究的热点。

关键词： 心理痛；生理痛；脑岛；扣带回；前额叶皮层

分类号：Q423;B845.2;Q582

A sketch of the overlap in the neural circuitry underlying psychological- and physical-pain

YU Wen-Jun^1,2, JIANG Jin-Xiang¹, Yang Li^1,*

¹School of Psychology, South China Normal University, Guangzhou 510631, China；²College of Education, Jinggangshan University, Ji’an 343009, China

Abstract

From the phenomenological point of view, pain can be classified into psychological-pain and physical-pain. Emerging evidence has shown that the psychological- and physical-pain recruit overlapping neural activity in regions associated with the affective component of pain, and share some common pain circuits, e.g., the dorsal anterior cingulate cortex (dACC) and the anterior insula (AI) play important roles in both psychological- and physical-pain. Therefore, understanding the way in which psychological- and physical-pain demonstrate either similarity or discrepancy may provide new insights into the relationship between the two types of experiences and potential targets for treating psychological suffering. This review summarizes research progress that has been obtained through experiments conducted in human and nonhuman animals to discuss the similarity, discrepancy and interaction between psychological- and physical-pain. The important next steps, e.g., uncovering the mechanisms underlying the overlap of psychological- and physical-pain; and whether chronic psychological-pain shapes brain plasticity as physical-pain does, are also discussed.

Key words: psychological pain

收稿日期：2017-04-27　　录用日期：2017-08-30

通讯作者：杨莉　　E-mail: yang_li@m.scnu.edu.cn

DOI: 10.13294/j.aps.2017.0058

引用本文：

于文军, 江锦祥, 杨莉. 心理痛与生理痛的共享神经机制[J]. 生理学报 2017; 69 (6): 830-842.

YU Wen-Jun, JIANG Jin-Xiang, Yang Li. A sketch of the overlap in the neural circuitry underlying psychological- and physical-pain. Acta Physiol Sin 2017; 69 (6): 830-842 (in Chinese with English abstract).