过刊浏览

一氧化氮相关的巯基亚硝基化修饰及其对血管功能的调控

李婧, 冯娟, 王宪^*

北京大学基础医学院生理学与病理生理学系；分子心血管学教育部重点实验室，北京 100191

摘要

一氧化氮(nitric oxide, NO)作为重要的血管舒张活性因子已成共识。近年来，NO的非cGMP依赖调控机制——巯基亚硝基化修饰受到广泛关注。巯基亚硝基化属于蛋白质翻译后修饰，广泛参与调控生物体内各种生理病理过程。本综述将从NO相关的蛋白质巯基亚硝基化的发生和调控等方面简要介绍近年来相关工作的研究进展，并着重阐述巯基亚硝基化修饰在血管生理及相关疾病中发挥的调节作用。

关键词： 一氧化氮; 巯基亚硝基化 ; 去亚硝基化 ; 血管疾病

分类号：R363

Regulation of vascular function by nitric oxide-related S-nitrosylation

Li Jing, Feng Juan, Wang Xian^*

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Key laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, China

Abstract

Nitric oxide (NO), well known as the endothelium-derived relaxing factor (EDRF), has become increasingly recognized as an important determinant of cardiovascular diseases. A molecular pathway by which NO accomplishes various biochemical processes is the cGMP-independent post-translational modification of protein, S-nitrosylation. Here we review the biochemistry and regulating mechanisms of NO-related S-nitrosylation of proteins, and discuss the multiple roles of S-nitrosylation in vascular functions and pathology in particular.

Key words: Nitric oxide; S-nitrosylation ; denitrosylation ; cardiovascular disease

收稿日期：2017-04-25　　录用日期：2017-07-28

通讯作者：王宪　　E-mail: xwang@bjmu.edu.cn

DOI: 10.13294/j.aps.2017.0069

引用本文：

李婧, 冯娟, 王宪. 一氧化氮相关的巯基亚硝基化修饰及其对血管功能的调控[J]. 生理学报 2017; 69 (5): 557-570.

Li Jing, Feng Juan, Wang Xian. Regulation of vascular function by nitric oxide-related S-nitrosylation. Acta Physiol Sin 2017; 69 (5): 557-570 (in Chinese with English abstract).