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整合素参与间充质干细胞分化

闪海燕, 张蕾

昆明医科大学附属甘美医院(昆明市第一人民医院)生物医学实验中心，昆明 650011

摘要

整合素是一类跨膜受体，是由α和β两个亚单位组成的异二聚体，主要通过与细胞外基质(extracellular matrix, ECM)相互作用将外界信号传入细胞内，并且在细胞生存、迁移、分化等多种细胞生命活动中发挥关键作用。具有多向分化潜能的间充质干细胞(mesenchymal stem cells, MSCs)的分化依赖整合素参与的信号通路，涉及MAPK、Wnt、PI3K信号通路等，而整合素的表达与活化受多种因素影响，如纳米形态微环境、抗坏血酸、骨成型蛋白-2、纤连蛋白、钙粘素、流体切应力等。本文主要对整合素表达的影响因素、整合素促进MSCs分化及其机制方面进行综述。

关键词： 整合素; 间充质干细胞 ; 信号通路; 细胞分化

分类号：Q2.33

Effects of integrin on differentiation of mesenchymal stem cells

SHAN Hai-Yan, ZHANG Lei

Biomedical Research Center, Affiliated Calmette Hospital of Kunming Medical University (First Hospital of Kunming), Kunming 650011, China

Abstract

Integrin is a family of transmembrane heterodimer receptor formed by α and β two subunits, which transduces external signals into cells through reaction with extracellular matrix and is crucial to cell survival, migration, and differentiation. With the deep studies on multipotential differentiation of mesenchymal stem cells (MSCs), researchers found that the differentiation of MSCs depends on integrin related signaling pathways, including MAPK, Wnt and PI3K signaling pathways and so on. However, there are many factors affecting the expression and activation of integrin, such as nano morphology microenvironment, ascorbic acid, bone morphogenetic protein-2, fibronectin, cadherin, fluid shear stress and so on. In this review, we mainly discuss the integrin expression, the promoting effects of integrin on the differentiation of MSCs and their underlying mechanisms.

Key words: integrin; mesenchymal stem cells ; signaling pathway; cell differentiation

收稿日期：2017-02-21　　录用日期：2017-05-25

通讯作者：张蕾　　E-mail: zlei01@hotmail.com

引用本文：

闪海燕, 张蕾. 整合素参与间充质干细胞分化[J]. 生理学报 2017; 69 (4): 498-508.

SHAN Hai-Yan, ZHANG Lei. Effects of integrin on differentiation of mesenchymal stem cells. Acta Physiol Sin 2017; 69 (4): 498-508 (in Chinese with English abstract).