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钾通道与自噬

杨硕, 刘佳, 屈超, 孙佳, 张炳强, 孙亚如, 邹伟

辽宁师范大学生命科学学院，大连 116081；卫生部细胞移植重点实验室临床中心，青岛 266000；大连理工大学生命科学与技术学院，大连 116024

摘要

K+通道是广泛分布于细胞膜上、亚型众多的一类离子通道，它们通过参与静息电位形成、物质运输、酶活性和胞间通讯等过程影响细胞的多种生理功能。自噬是机体维持细胞内代谢平衡的一种重要机制，自噬的异常会导致多种疾病的发生和发展。新近文献报道，钾通道与细胞的自噬密切相关。本文简要综述了K+通道调节自噬通路、自噬通量或自噬溶酶体形成等方面的研究进展，并探讨了K+通道调控细胞自噬的生理学意义。

关键词： 离子通道; 钾通道 ; 自噬

分类号：Q291

Potassium channels and autophagy

YANG Shuo, LIU Jia, QU Chao, SUN Jia, ZHANG Bing-Qiang, SUN Ya-Ru, ZOU Wei

College of Life Sciences, Liaoning Normal University, Dalian 116081, China； Key Laboratory of Cell Transplantation, Ministry of Health, Qingdao 266000, China； Department of Biological Science and Technology, Dalian University of Technology, Dalian 116024, China

Abstract

Potassium channels have multitudinous subtypes, which are widely distributed on cell membranes. They affect various cellular physiological functions through participating in processes such as resting potential formation, substance transportation, enzyme activity and cellular communication. Autophagy is a significant mechanism to maintain intracellular metabolic homeostasis. The abnormity of autophagy may lead to the occurrence and development of multiple diseases. Recently, it has been reported that K+ channels and cell autophagy are closely related. Here, we reviewed the recent research progresses on regulation of autophagy signaling, autophagy flux or autophagolysosome formation by K+ channel, and discussed the physiological significance of autophagy regulation by K + channel.

Key words: Ion channel; potassium channel ; autophagy

收稿日期：2016-11-14　　录用日期：2017-04-10

通讯作者：邹伟　　E-mail: weizou60@126.com

引用本文：

杨硕, 刘佳, 屈超, 孙佳, 张炳强, 孙亚如, 邹伟. 钾通道与自噬[J]. 生理学报 2017; 69 (4): 509-514.

YANG Shuo, LIU Jia, QU Chao, SUN Jia, ZHANG Bing-Qiang, SUN Ya-Ru, ZOU Wei. Potassium channels and autophagy. Acta Physiol Sin 2017; 69 (4): 509-514 (in Chinese with English abstract).