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自分泌运动因子-溶血磷脂酸轴的生物学功能与调控

李宗伟，赵亚蕊，赵 超，付 荣，李卓玉*

山西大学生物技术研究所，化学生物学与分子工程教育部重点实验室，太原 030006

摘要

自分泌运动因子(autotaxin, ATX)也称作磷酸二酯酶Iα，是核苷酸焦磷酸酶/磷酸二酯酶家族(nucleotide pyrophosphatases, NPPs)中的一员，因而也称作NPP2。ATX是NPPs中唯一具有溶血磷脂酶D (lysophospholipase D, lysoPLD)活性的成员，它可以将溶血磷脂胆碱(lysophosphatidylcholine, LPC)水解成溶血磷脂酸(lysophosphatidic acid, LPA)。LPA则通过结合特异的G蛋白耦联受体(G-protein-coupled receptor, GPCR)发挥广泛的生物学效应，包括细胞增殖、迁移和细胞收缩等。ATX作为LPA生成的最主要磷脂酶，其许多功能的发挥与LPA密切相关，二者组成一个ATX-LPA功能轴。本文主要综述了近年来ATX-LPA轴的生物学功能和调控方面的相关研究进展。

关键词： 自分泌运动因子; 溶血磷脂酶D; 溶血磷脂酸

分类号：Q2

[Function and biological activities of the autotaxin-LPA axis.] [Article in Chinese]

LI Zong-Wei, ZHAO Ya-Rui, ZHAO Chao, FU Rong, LI Zhuo-Yu*

Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan 030006, China

Abstract

Autotaxin (ATX), a member of nucleotide pyrophosphatase/phosphodiesterase (NPP) family, is also named as phosphodiesterase Iα (PD-Iα) or NPP2. ATX is the unique member among the NPPs that can function as a lysophospholipase D (lysoPLD), converting lysophosphatidylcholine into lysophosphatidic acid (LPA). LPA acts on specific G-protein-coupled receptors to elicit a wide range of cellular response, including cell proliferation, cell migration and cell contraction, etc. As the major LPA-producing phospholipase, many ATX’s features and functions are dependent on the production of LPA. ATX and LPA together form the ATX-LPA functional axis. The present review summarizes the current progress in function and biological activities of ATX-LPA axis.

Key words: autotoxin; lysophospholipase D; lysophosphatidic acid

收稿日期：2011-04-28　　录用日期：2011-06-29

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引用本文：

李宗伟，赵亚蕊，赵 超，付 荣，李卓玉* . 自分泌运动因子-溶血磷脂酸轴的生物学功能与调控[J]. 生理学报 2011; 63 (6): 601-610.

LI Zong-Wei, ZHAO Ya-Rui, ZHAO Chao, FU Rong, LI Zhuo-Yu*. [Function and biological activities of the autotaxin-LPA axis.] [Article in Chinese]. Acta Physiol Sin 2011; 63 (6): 601-610 (in Chinese with English abstract).