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内脏平滑肌Cajal 间质细胞起搏功能

黄旭, 许文燮^*

Department of Physiology, Shanghai Jiaotong University School of Medicine, Shanghai 200240, China

摘要

胃肠道的大部分区域都存在着一种特殊的间质细胞——Cajal 间质细胞(interstitial cells of Cajal, ICCs)。尽管在100 多年前它们的存在就已被发现，但是直到最近几十年的研究才逐渐揭示了它们的功能。在胃肠道，ICCs 被认为是平滑肌自发性节律性电活动，即“基本电节律”( 又称“慢波”) 的起搏细胞，并介导神经至平滑肌的神经信号传递活动。除胃肠道外，ICC 样细胞同样存在于其它内脏平滑肌，如泌尿、生殖系统以及血管平滑肌等。本文仅就这些内脏平滑肌ICCs 的功能做一简单综述。

关键词： Cajal 间质细胞; 起搏细胞; 神经传递

分类号：R318.14

The pacemaker functions of visceral interstitial cells of Cajal

HUANG Xu, XU Wen-Xie^*

上海交通大学医学院生理教研室，上海 200240

Abstract

Interstitial cells of Cajal (ICCs) are located in most parts of the digestive system. Although they have been found over 100years, their functions began to be unravelled only recently. ICCs are considered as pacemaker cells which elicit spontaneous rhythmicelectric activity termed “basic electrical rhythm” or “slow waves” in gastrointestinal tract. Moreover, they also mediate neurotransmissionfrom neurons to smooth muscle in gastrointestinal tract. ICC-like cells also exist in other visceral smooth muscles, such asurinary tract, genital system and vascular smooth muscle. In this paper we review the progress of research about the functions ofvisceral ICCs.

Key words: interstitial cells of Cajal; pacemaker cells; neurotransmission

收稿日期：2010-08-11　　录用日期：2010-09-15

通讯作者：许文燮　　E-mail: wenxiexu@sjtu.edu.cn

引用本文：

黄旭, 许文燮. 内脏平滑肌Cajal 间质细胞起搏功能[J]. 生理学报 2010; 62 (5): 387-397.

HUANG Xu, XU Wen-Xie. The pacemaker functions of visceral interstitial cells of Cajal. Acta Physiol Sin 2010; 62 (5): 387-397 (in Chinese with English abstract).