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SUMO化对DAXX亚细胞定位与功能影响的研究进展

李玲, 文娟, 庹勤慧, 廖端芳

南华大学药物药理研究所，衡阳 421001；湖南中医药大学药学部中医诊断学系，长沙 410208

摘要

死亡结构域相关蛋白(death domain-associated protein, DAXX)是一个多功能的核蛋白，广泛分布于核仁、核质、染色质、早幼粒细胞白血病蛋白核体(PML-NBs)和胞浆等亚细胞区域，对细胞的转录调控、凋亡及细胞周期等生物学活动发挥重要作用。SUMO化修饰(small ubiquitin-like modification)是一种重要的、高度保守的翻译后生物学修饰，大量文献显示SUMO化修饰对DAXX的亚细胞定位及功能的调节具有重要意义。本文对此方面的研究进展做一综述。

关键词： 小泛素相关修饰蛋白; 死亡结构域相关蛋白; 亚细胞定位; 小泛素化

分类号：R363

[Effects of SUMOylation on the subcellular localization and function of DAXX.] [Article in Chinese]

Li Ling, WEN Juan, TUO Qin-Hui, LIAO Duan-Fang

Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, China； School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China

Abstract

Death domain-associated protein (DAXX) as a multifunctional nuclear protein widely resides in nucleolus, nucleoplasm, chromatin, promyelocytic leukaemia nuclear bodies (PML-NBs) and cytoplasm. It plays significant roles in transcriptional regulation, apoptosis, cell cycle and other biological activities. Small ubiquitin-like modifier (SUMO) is required for SUMOylation which is a highly conserved post-translational modification in a wide variety of cellular processes. Numerous studies demonstrated that SUMOylation has a great effect on the subcellular localization and functional regulation of DAXX. This review will provide a summary for SUMOylation of DAXX.

Key words: small ubiquitin-like modifier; death domain-associated protein; subcellular localization; SUMOylation

收稿日期：2012-05-10　　录用日期：2012-08-20

通讯作者：庹勤慧　　E-mail: qhtuo@yahoo.com.cn

引用本文：

李玲, 文娟, 庹勤慧, 廖端芳. SUMO化对DAXX亚细胞定位与功能影响的研究进展[J]. 生理学报 2013; 65 (1): 89-95.

Li Ling, WEN Juan, TUO Qin-Hui, LIAO Duan-Fang. [Effects of SUMOylation on the subcellular localization and function of DAXX.] [Article in Chinese]. Acta Physiol Sin 2013; 65 (1): 89-95 (in Chinese with English abstract).