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糖尿病大鼠外周神经山梨醇通路和Na~(+)-K~(+)-ATP酶活性的变化

吕康模, 钟学礼, 朱禧星, 朱秋毓

上海医科大学华山医院

摘要

糖尿病发生4wk后, 坐骨神经葡萄糖含量增加3—4倍, 果糖增加3—5倍, 山 梨醇增加6—9倍, 肌醇含量降低到对照组的50%, 总ATP酶和哇巴因敏感的Na~ (+)-K~(+)-ATP酶活性均极显著地低于同龄对照组(P<0.01)。结果提示这些 代谢变化可能是糖尿病病变发病机制中的重要环节。

Alterations in the sorbitol pathway and Nasuper(+)-Ksuper(+)-ATPaseactivity of peripheral nerve of alloxan-induced diabetic rats

Lu Kangmo, Zhong Xueli, Zhu Xixing, Zhu Qiuyue

Huashan Hosp., Shanghai Med. Univ.

Abstract

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引用本文：

吕康模, 钟学礼, 朱禧星, 朱秋毓. 糖尿病大鼠外周神经山梨醇通路和Na~(+)-K~(+)-ATP酶活性的变化[J]. 生理学报 1990; 42 (4): .

Lu Kangmo, Zhong Xueli, Zhu Xixing, Zhu Qiuyue. Alterations in the sorbitol pathway and Nasuper(+)-Ksuper(+)-ATPaseactivity of peripheral nerve of alloxan-induced diabetic rats. Acta Physiol Sin 1990; 42 (4): (in Chinese with English abstract).