过刊浏览

神经精神疾病中的催产素系统：老概念，新见解

MISRANI Afzal, TABASSUM Sidra, 龙程

华南师范大学1生命科学学院；脑科学研究院，广州 510631

摘要

催产素(oxytocin, OXT)是一种神经肽，在各物种的中枢和外周神经系统中都起着关键作用。由于它参与焦虑相关行为、压力调节、社会行为和各种神经精神障碍，近年引起大量关注。OXT是介导诸如母性行为、恐惧消退、社会支持、幸福与信任之类的情感和社会行为的重要物质之一，也参与学习和记忆过程。OXT系统的最新进展已将此神经肽用于心理治疗干预各种神经精神疾病，如压力、焦虑障碍、社交恐惧症、产后忧郁症、躁郁症、自闭症和精神分裂症等。本综述着重概括OXT对各种生理功能和心理问题的贡献，并讨论其作为治疗药物的潜力。

关键词： 催产素; 压力 ; 焦虑 ; 恐惧 ; 自闭 ; 神经精神疾病

分类号：R74;Q42

Oxytocin system in neuropsychiatric disorders: Old concept, new insights

MISRANI Afzal, TABASSUM Sidra, LONG Cheng

School of Life Sciences； Institue of Brain Science, South China Normal University, Guangzhou 510631, China

Abstract

Oxytocin (OXT) is a neuropeptide that plays a pivotal role among species peripherally and centrally. It recently has attracted much attention for its involvement in anxiety-related behavior, stress regulation, social behavior and various neuropsychiatric disorders. OXT is one of the important mediators of emotional and social behaviors such as maternal behavior, fear extinction, social support, happiness, and trust. It is also involved in learning and memory process. The recent progresses in OXT system have put this neuropeptide as an important psychotherapeutic intervention for various psychiatric disorders such as stress, anxiety disorders, social phobia, postpartum depression, bipolar disorder, autism, and schizophrenia. In this review, we highlight OXT’s contributions to various physiological functions and psychological disorders and discuss its potential use as a therapeutic agent.

Key words: Oxytocin; stress ; anxiety ; fear ; autism ; schizophrenia

收稿日期：2016-08-04　　录用日期：2016-10-28

通讯作者：　　E-mail:

引用本文：

MISRANI Afzal, TABASSUM Sidra, 龙程. 神经精神疾病中的催产素系统：老概念，新见解[J]. 生理学报 2017; 69 (2): 196-206.

MISRANI Afzal, TABASSUM Sidra, LONG Cheng. Oxytocin system in neuropsychiatric disorders: Old concept, new insights. Acta Physiol Sin 2017; 69 (2): 196-206