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血管中膜钙化的机制

刘艺涵, 孔炜^*

北京大学医学部生理学与病理生理学系，北京 100191

摘要

血管钙化是一个主动的、可逆转的并且受到高度调控的病理过程，其特点是羟磷灰石结晶沉积于血管系统。血管钙化可分为血管内膜钙化和血管中膜钙化等。血管中膜钙化常见于糖尿病、慢性肾功能衰竭及衰老的血管中。本文主要综述了血管中膜钙化的相关机制。

关键词： 血管钙化; 血管平滑肌细胞; 机制

分类号：R363.2+1

[The mechanisms of medial vascular calcification .] [Article in Chinese]

LIU Yi-Han, KONG Wei^*

Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China

Abstract

Vascular calcification is an active, invertible and highly regulated pathophysiological process, characterized by the deposition of hydroxyapatite crystal in vascular wall. Vascular calcification is classified into two types based on the sites of calcification: intimal atherosclerotic calcification and Mönckeberg’s medial calcification. Medial vascular calcification is a pathological phenomenon commonly existed in diabetes, chronic kidney failure and aging. The current review summarizes the mechanisms of medial vascular calcification.

Key words: vascular calcification; vascular smooth muscle cells; mechanism

收稿日期：2016-04-05　　录用日期：2016-07-08

通讯作者：孔炜　　E-mail: kongw@bjmu.edu.cn

引用本文：

刘艺涵, 孔炜. 血管中膜钙化的机制[J]. 生理学报 2016; 68 (5): 592-610.

LIU Yi-Han, KONG Wei. [The mechanisms of medial vascular calcification .] [Article in Chinese]. Acta Physiol Sin 2016; 68 (5): 592-610 (in Chinese with English abstract).