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葡萄糖转运体4与高脂膳食诱导的认知改变和海马内葡萄糖代谢的关系

张云丽^*, 王林1

1上海体育学院运动科学学院，上海市人类运动能力开发与保障重点实验室，上海 200438；2聊城大学体育学院理论教研室，聊城 252059

摘要

海马不仅参与学习和记忆，而且对食欲和能量平衡也发挥作用。阐明海马内葡萄糖转运体4 (glucose transporter 4, GLUT4)与海马依赖性认知功能改变以及海马内葡萄糖代谢之间的关系，对深入理解营养性肥胖和糖尿病相关疾病的病理生理基础以及治疗认知功能障碍有重要意义。本文对近年来海马内GLUT4与海马依赖性认知功能改变以及海马内葡萄糖代谢之间关系的相关研究进行综述，主要探讨：(1) GLUT4的结构和海马内分布及功能；(2)海马内GLUT4转位；(3) PI3K-Akt-
GLUT4信号通路与高脂膳食诱导的认知功能改变以及海马内葡萄糖代谢的关联；(4)海马内PI3K-Akt-GLUT4信号通路与糖尿病相关的认知功能障碍的关联；(5)葡萄糖代谢异常引起认知功能障碍的可能机制。

关键词： 葡萄糖转运体4; 海马; 葡萄糖代谢; 学习和记忆

Relationships of glucose transporter 4 with cognitive changes induced by high fat diet and glucose metabolism in hippocampus

ZHANG Yun-Li^*, WANG Lin

1Shanghai Key Laboratory of Human Sport Competence Development and Maintenance, School of Sport Science, Shanghai University of Sport, Shanghai 200438, China； 2Theory Teaching and Research Section, Department of Physical Education, Liaocheng University,Liaocheng 252059, China

Abstract

The hippocampus not only plays a role in appetite and energy balance, but also is particularly important in learning andmemory. Figuring out the relationships of hippocampal glucose transporter 4 (GLUT4) with hippocampal glucose metabolism and
hippocampus-dependent cognitive function is very important to clearly understand the pathophysiological basis of nutritional obesity and diabetes-related diseases, and treat obesity and cognitive dysfunction. Therefore, this study reviewed recent researches conducted on hippocampal GLUT4, hippocampal glucose metabolism, and hippocampus-dependent cognitive function. In this review, we mainly discussed: (1) The structure of GLUT4 and the distribution and function of GLUT4 in the hippocampus; (2) The translocation of GLUT4 in the hippocampus; (3) The relationships of the PI3K-Akt-GLUT4 signaling pathway with the high fat diet-induced changes of cognitive function and the glucose metabolism in the hippocampus; (4) The associations of the PI3K-Akt-GLUT4 signaling pathway with the diabetes-related cognitive dysfunction in the hippocampus; (5) The potential mechanisms of cognitive dysfunction induced
by glucose metabolic disorder.

Key words: glucose transporter 4; hippocampus; glucose metabolism; learning and memory

收稿日期：　　录用日期：

通讯作者：张云丽　　E-mail: zhangyunli@lcu.edu.cn

引用本文：

张云丽, 王林1. 葡萄糖转运体4与高脂膳食诱导的认知改变和海马内葡萄糖代谢的关系[J]. 生理学报 2016; 68 (3): 335-342.

ZHANG Yun-Li, WANG Lin. Relationships of glucose transporter 4 with cognitive changes induced by high fat diet and glucose metabolism in hippocampus. Acta Physiol Sin 2016; 68 (3): 335-342 (in Chinese with English abstract).