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真核翻译起始因子4G与肿瘤

张思, 黄楠, 潘霞, 臧婧蕾, 管馨馨, 张建华, 刘柳成, 雷小勇^*

南华大学药物药理研究所，衡阳 421000

摘要

真核翻译起始因子4G (eukaryotic translation initiation factor 4G, eIF4G)是eIF4F复合物中的一种“支架蛋白”，在蛋白质合成的起始阶段中发挥重要的调控作用。近年来研究表明，eIF4G的两个亚型eIF4G1和eIF4G2跟许多恶性肿瘤的调控有密切关系，相对于相应的正常组织，eIF4G1在乳腺癌、宫颈癌、鼻咽癌、肺鳞状细胞癌、前列腺癌等恶性肿瘤中表达明显增高；而eIF4G2在弥漫性大B细胞淋巴瘤、急性髓细胞性白血病、膀胱移行细胞癌也有明显的差异性表达。因此，本文主要总结eIF4G、eIF4G1和eIF4G2的表达情况对肿瘤发生、发展及预后的影响，为肿瘤早期预测、靶向治疗及预后提供更好的理论依据。

关键词： 真核翻译起始因子4G (eIF4G); eIF4G1; eIF4G2; 肿瘤

分类号：R73

[Role of eukaryotic translation initiation factor 4G in tumor.] [Article in Chinese]

ZHANG Si, HUANG Nan, PAN Xia, ZANG Jing-Lei, GUAN Xin-Xin, ZHANG Jian-Hua, LIU Liu-Cheng, LEI Xiao-Yong^*

Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421000, China

Abstract

Eukaryotic translation initiation factor 4G (eIF4G) is a scaffold component of eukaryotic translation initiation factor 4F (eIF4F) complex, which takes principal part in the initiating of protein synthesis. Both two subtypes (eIF4G1 and eIF4G2) of eIF4G were found to be closely related with various tumors. The eIF4G1 expression is significantly up-regulated in breast cancer, cervical cancer, nasopharyngeal carcinoma, lung squamous cell carcinoma, prostatic carcinoma and other malignant tumors, compared with those in adjacent tissues; and the eIF4G2 is obviously over-expressed in diffuse large B cell lymphoma and acute myeloid leukemia, but low-expressed in bladder transitional cell carcinoma. This paper reviews the progress in the study of the role of eIF4G in tumor genesis, development, diagnosis and prognosis.

Key words: eukaryotic translation initiation factor 4G (eIF4G); eIF4G1; eIF4G2; tumor

收稿日期：2015-11-20　　录用日期：2016-02-17

通讯作者：雷小勇　　E-mail: 1622214323@qq.com

引用本文：

张思, 黄楠, 潘霞, 臧婧蕾, 管馨馨, 张建华, 刘柳成, 雷小勇. 真核翻译起始因子4G与肿瘤[J]. 生理学报 2016; 68 (2): 207-214.

ZHANG Si, HUANG Nan, PAN Xia, ZANG Jing-Lei, GUAN Xin-Xin, ZHANG Jian-Hua, LIU Liu-Cheng, LEI Xiao-Yong. [Role of eukaryotic translation initiation factor 4G in tumor.] [Article in Chinese]. Acta Physiol Sin 2016; 68 (2): 207-214 (in Chinese with English abstract).