过刊浏览

维持原始卵泡静息状态的相关信号分子及通路

胡燎燎, 向晟, 郑莉萍^*

南昌大学江西医学院医学实验教学中心，南昌 330031

摘要

雌性哺乳动物生殖寿命与原始卵泡池大小有关，而原始卵泡池大小有赖于原始卵泡“启动”及“静息”之间的平衡，故有关其生长启动以及静息状态维持的分子机制成为近年研究热点。大量研究表明，某些基因突变、卵巢局部自分泌或旁分泌因子、原癌基因或抑癌基因参与了原始卵泡启动及静息状态的维持。本文就维持原始卵泡静息状态的重要信号分子和通路方面的研究进展进行综述。

关键词： 原始卵泡; 静息状态; 信号分子

分类号：R3

[Signaling molecules and pathways involved in maintaining the quiescence of primordial follicles.] [Article in Chinese]

HU Liao-liao, XIANG Cheng, ZHENG Li-Ping^*

Medical Experimental Teaching Department, Jiangxi Medical College of Nanchang University, Nanchang 330031, China

Abstract

Clarifying the regulation mechanisms of primordial follicle initiation is crucial for the prevention of premature ovarian failure and treatment of female infertility. Reproductive lifespan in female mammals is related to the size of primordial follicles pool which relies on the balance between activated and quiescent primordial follicles, therefore, the molecular mechanisms underlying recruiting quiescence primordial follicles have become a hotspot recently. Multiple studies have shown that genetic mutations, local ovarian autocrine and paracrine factors, proto-oncogene andtumor-suppressor genes involved in the maintenance of balance between quiescence and activated primordial follicles. In the present review, we summarize the important signaling molecules and pathways that maintain the quiescence of primordial follicles to provide insight for prolonging reproductive lifespan.

Key words: primordial follicles; quiescent state; signaling molecules

收稿日期：2014-08-07　　录用日期：2014-10-13

通讯作者：郑莉萍　　E-mail: zhengliping@ncu.edu.cn

引用本文：

胡燎燎, 向晟, 郑莉萍. 维持原始卵泡静息状态的相关信号分子及通路[J]. 生理学报 2015; 67 (1): 59-64.

HU Liao-liao, XIANG Cheng, ZHENG Li-Ping. [Signaling molecules and pathways involved in maintaining the quiescence of primordial follicles.] [Article in Chinese]. Acta Physiol Sin 2015; 67 (1): 59-64 (in Chinese with English abstract).