过刊浏览

PI3K/Akt信号通路调控胚胎干细胞的自我更新和多向分化潜能的研究进展

尹盟盟, 崔玉荣, 王璐, 王佳玉, 高颖, 席姣娅^*

华中科技大学同济医学院基础医学院生理学系，中德干细胞中心，药物靶点研究与药效学评价湖北省重点实验室，武汉 430030

摘要

磷脂酰肌醇3-激酶(phosphatidylinositol 3-kinase, PI3K)及其下游靶点蛋白激酶B (protein kinase B, Akt/PKB)可被细胞内外一系列信号所激活，在增殖、分化、凋亡等多种细胞生物学功能的调节过程中，起着非常重要的关键信号分子的作用。近年来研究显示，I型PI3K和其下游分子Akt/PKB所组成的信号通路与胚胎干细胞(embryonic stem cells, ES细胞)自我更新和多向分化潜能的维持密切相关。深入研究ES细胞自我更新和多向分化潜能的维持及其分子机制，是其应用于细胞替代治疗、再生医学和组织工程的基础。本文着重对PI3K/Akt信号通路调控ES细胞自我更新和多向分化潜能的研究进展进行综述。

关键词： PI3K/Akt信号通路; 胚胎干细胞; 自我更新; 多向分化潜能

分类号：R329; Q813

[Progress on PI3K/Akt signaling pathway regulating self-renewal and pluripotency of embryonic stem cells.] [Article in Chinese]

YIN Meng-Meng, CUI Yu-Rong, WANG Lu, WANG Jia-Yu, GAO Ying, XI Jiao-Ya^*

Department of Physiology and Chinese-German Stem Cell Center, Tongji Medical College, Huazhong University of Science and Technology, The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan 430030, China

Abstract

The phosphatidylinositol 3-kinase (PI3K) and its downstream target protein kinase B (Akt/PKB) can be activated by a variety of extracellular and intracellular signals. They are important signaling molecules and key survival factors involved in cell proliferation, differentiation, apoptosis and other cellular processes. Recently, many reports demonstrate that type I PI3K/Akt signaling pathway plays an important role in maintenance of self-renewal and pluripotency of embryonic stem (ES) cells. Further studies with regard to the self-renewal and pluripotency of ES cells and underlying molecular mechanisms are crucial to its application in cell replacement therapy, regenerative medicine and tissue engineering. The present review focuses on the recent progress on the mediation of PI3K/Akt signaling pathway on the maintenance of self-renewal and pluripotency of ES cells.

Key words: PI3K/Akt signaling pathway; embryonic stem cells; Self-renewal; pluripotency

收稿日期：2013-07-29　　录用日期：2014-01-02

通讯作者：席姣娅　　E-mail: zhengyall@hotmail.com

引用本文：

尹盟盟, 崔玉荣, 王璐, 王佳玉, 高颖, 席姣娅. PI3K/Akt信号通路调控胚胎干细胞的自我更新和多向分化潜能的研究进展[J]. 生理学报 2014; 66 (2): 223-230.

YIN Meng-Meng, CUI Yu-Rong, WANG Lu, WANG Jia-Yu, GAO Ying, XI Jiao-Ya. [Progress on PI3K/Akt signaling pathway regulating self-renewal and pluripotency of embryonic stem cells.] [Article in Chinese]. Acta Physiol Sin 2014; 66 (2): 223-230 (in Chinese with English abstract).