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尼古丁摄入量和吸烟后急性心率反应预测相同的尼古丁依赖程度?

Jerome F Walker, Paul Loprinzi, Christy J Kane

贝拉明大学呼吸治疗系；运动生理学系，路易维登 40205，美国

摘要

本研究采用吸烟摄入尼古丁量和心脏对吸烟的心率敏感性两个测量尼古丁依赖性的量表，比较这两个量表预测尼古丁的依赖性是否相同。15名长期吸烟男性，隔夜禁食后清晨给予第一支香烟，分别测量吸烟前、吸烟后5、10、15和30 min的心率和血液的尼古丁含量。结果显示，心率敏感性和尼古丁摄入量没有直接线性相关，而是曲线关系。心率敏感性在尼古丁摄入量达到70%时有显著增加。

关键词： 烟草用量紊乱; 尼古丁依赖; 尼古丁用量紊乱 -分类

分类号：R331

Do nicotine intake and acute heart rate response to smoking rank nicotine dependence the same?

Jerome F Walker, Paul Loprinzi, Christy J Kane

Department of Respiratory Therapy； Department of Exercise Physiology, Bellarmine University, Louisville 40205, KY, USA

Abstract

In this study, two proposed scales of nicotine dependence were compared: self-administered nicotine intake and acute heart rate sensitivity to smoking. Our aim was to determine if these nicotine dependence scales would rank relative dependence the same in a sample of 15 male chronic smokers who smoked their first cigarette in the morning after overnight abstinence. Heart rate and plasma nicotine levels were measured before and 5, 10, 15, and 30 min after smoking. The results of this pilot study suggest that heart rate sensitivity and nicotine intake do not have a direct linear relationship, but rather a curvilinear relationship. A marked increase in heart rate sensitivity was observed at approximately the 70th percentile of nicotine intake.

Key words: tobacco use disorder; nicotine dependence; nicotine use disorder-classification

收稿日期：2012-12-20　　录用日期：2013-03-11

通讯作者：Jerome F Walker　　E-mail: jwalker@bellarmine.edu

引用本文：

Jerome F Walker, Paul Loprinzi, Christy J Kane. 尼古丁摄入量和吸烟后急性心率反应预测相同的尼古丁依赖程度?[J]. 生理学报 2013; 65 (3): 319-322.

Jerome F Walker, Paul Loprinzi, Christy J Kane. Do nicotine intake and acute heart rate response to smoking rank nicotine dependence the same?. Acta Physiol Sin 2013; 65 (3): 319-322 (in Chinese with English abstract).