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前庭功能的中枢组胺能神经调制

Bergquist F, Dutia M B

英国爱丁堡大学生物医学科学学院整合生理学中心.爱丁堡 EH8 9XD

摘要

组胺能药物已经长期用于治疗人类的平衡紊乱，但对于它们在前庭系统中作用的机制还缺乏了解。在该文中，作者综述了关于脑内(特别是脑干前庭核中)的组胺能神经传递，以及组胺在脑可塑性-----“前庭代偿”(一种单侧外周前庭损伤之后发生的行为学恢复)中作用的新近文献。作者在综述组胺能类药物促进前庭代偿证据的同时，也讨论了这类药物临床应用的可能性。

关键词： 组胺; 前庭系统; 可塑性; 前庭代偿

Central histaminergic modulation of vestibular function--a review

Bergquist F, Dutia M B

Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD

Abstract

Histaminergic drugs have long been used to treat balance disorders in man, but their mechanisms of action in the vestibular system are poorly understood. In this article we review the current literature on histaminergic neurotransmission in the brain focussing particularly in the brainstem vestibular nuclei, and the role of histamine in brain plasticity during “vestibular compensation”, the behavioural recovery that takes place after unilateral peripheral vestibular damage. Evidence that histaminergic compounds may facilitate vestibular compensation is reviewed, and we discuss the potential of histaminergic drugs for clinical use.

Key words: Histamine;vestibular system;plasticity;vestibular compensation

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引用本文：

Bergquist F, Dutia M B. 前庭功能的中枢组胺能神经调制[J]. 生理学报 2006; 58 (4): .

Bergquist F, Dutia M B. Central histaminergic modulation of vestibular function--a review. Acta Physiol Sin 2006; 58 (4): (in Chinese with English abstract).