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生理学与基因组学：走向系统生物学

Allen W. Cowley, 梁明瑜

威斯康星医学院生理学系，密尔沃基，威斯康星州 53226，美国

摘要

近十年来，生理学与基因组学达到了空前的融合。尽管生理基因组学还是一个非常年轻的研究领域，系统生物学概念的引入必将推进生理基因组学达到全新的水平。该文概要地叙述了这个令人振奋的生理科学的新时代给生理学家带来的机遇和挑战，并以作者自己近十年来的经验为例，讨论了怎样通过扩展和延伸生理学与基因组学的结合，从而对生物学得到系统的理解。

关键词： 生理学; 基因组学; 系统生物学

Physiology and genomics: toward systems biology

Allen W. Cowley, Liang Mingyu

Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA

Abstract

The last ten years have seen an unprecedented merge of physiology and genomics. While the field of physiological genomics is still very young, the introduction of the concept of systems biology promises to propel physiological genomics to a whole new level. In this brief article, we outlined some of the great opportunities and challenges for physiologists at this exciting time of physiological sciences, and used our own experience from the last ten years as an example to discuss how we could expand and go beyond the combination of physiology and genomics to achieve a systems understanding of biology.

Key words: Physiology;Genomics;Systems biology

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引用本文：

Allen W. Cowley, 梁明瑜. 生理学与基因组学：走向系统生物学[J]. 生理学报 2006; 58 (1): .

Allen W. Cowley, Liang Mingyu. Physiology and genomics: toward systems biology. Acta Physiol Sin 2006; 58 (1): (in Chinese with English abstract).