过刊浏览

腺苷易化大鼠颈动脉窦压力感受器的活动

陈爽, 范振中, 何瑞荣

河北医科大学基础医学研究所生理室. 石家庄 050017

摘要

在36只麻醉大鼠，以隔离灌流颈动脉窦区记录窦神经传入放电的方法观察了腺苷（adenosine，Ado）对颈动脉窦压力感受器传入放电的影响。所得结果如下：（1）以75μmol／LAdo隔离灌流大鼠左侧颈动脉窦区时，窦内压-窦神经传入放电积分（ISP－ISNA）关系曲线向左上方移位，曲线最大斜率（PS）由（18．75±0．12）％／kPa增至（22．21±0．11）％／kPa（P＜0．001），最大积分值（PIV）由（209．83±2．57）％增至（239．17±1．75）％。

关键词： 腺苷; 颈动脉窦; 窦神经传入放电

Cui Hong

First Clinical Institute，China Medical University. Shenyang 110001,Liaoning, China

Abstract

The effects of adenosine (Ado) on the carotid baroreceptor were studied in 36anesthetized rats with isolated carotid sinus perfusion by recording the sinus nerve afferentactivity. The results obtained were as follows: (1)By perfusing the isolated carotid sinuswith 75 μmol/L Ado, the functional curve for inbeinus pressure(ISP)-integral of sinusnerve activity (ISNA) relation was shifted to the left and upward with peak slope (PS)increased from (18.75±0. 12)%/kPa to (22. 21 ±10. 11) %/kPa (P<0.001) and thepeak integral value (PIV) enhanced from (209. 83 ±2. 57) % to (239. 17 ±1 .75) % (P<0.001), while the threshold pressure (TP) and saturation pressure (SP) weresignificantly decreased from 8.57 ± 0.24 to 7. 15 ± 0.23 kPa (P<0.001) and from22.99 ± 0.34 to 21 .21 ± 0.43 kPa (P<0.01). By perfusing with high concentrations ofAdo (125 and 175 μnol/L), the curves for ISP-ISNA relation were shifted to the left andupward further and the changes of the functional parameters such as PS, TP and SP weredose-dependent.

Key words: ;;

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

陈爽, 范振中, 何瑞荣. 腺苷易化大鼠颈动脉窦压力感受器的活动[J]. 生理学报 1998; 50 (5): .

Cui Hong. . Acta Physiol Sin 1998; 50 (5): (in Chinese with English abstract).