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迷走神经和交感神经系统不同活动状态对心率变异性的影响

李莉, 朱经武, 曹银祥, 李鹏

上海医科大学生理教研室. 上海 200032

摘要

实验在氯醛糖加氨基甲酸乙酯麻醉的新西兰兔上进行。记录血压、心率、心电图并对心电R－R间期（RRI）作功率谱密度（PSD）分析。以单调性电刺激和低频率的波动性电刺激分别刺激减压神经、疑核和右侧迷走神经外周端，观察到低频率的波动性刺激对增加PSD中低频成分（LF）的作用比单调性电刺激更大（P＜0．05）。注射新福林仅在头一个256个心动周期时间内引起总变异性（TV）、LF、PSD中高频成分（HF）。LF／HF比值和PSD中极低频成分（VLF）增大（P＜0．05～0．01）。

关键词： 心率变异性; 迷走神经; 交感神经系统; 电刺激; 紧张性变异

Cui Hong

First Clinical Institute，China Medical University. Shenyang 110001,Liaoning, China

Abstract

Experiments were performed on rabbits anaesthetized with urethane and chloralose.The electrocardiogram(ECG), heart rate (HR), and blood pressure(BP) wererecorded and the power spectrum density (PSD) of R-R interval was analysed by acomputer. The low frequency component (LF) was higher during the respectivestimulation of the nucleus ambiguus, depressor nerve, and the peripheral end of rightvagus with a low frequency fluctuant style than with a monotonous style (P<0.05).Intravenous infusion of phenylephrine resulted in increases of total variance of RRI (TV),very low frequency components (VLF), LF, high frequency components (HF) and LF/HF during the first 256 RRI only (P<0.05~0.01). In order to observe the influence ofdifferent activities of sympathetic nerves on heart rate variability (HRV), DLhomocysteine(DLH) was microinjected into the vicinity of N. Paraventricularis ofhypothalamus.

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引用本文：

李莉, 朱经武, 曹银祥, 李鹏. 迷走神经和交感神经系统不同活动状态对心率变异性的影响[J]. 生理学报 1998; 50 (5): .

Cui Hong. . Acta Physiol Sin 1998; 50 (5): (in Chinese with English abstract).