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α-黑色素细胞刺激素对白细胞介素-1β发热的解热机理研究

胡巢凤, 王华东, 王达安, 王彦平, 李楚杰

暨南大学医学院病理生理教研室发热研究室

摘要

本研究观察了α-黑色素细胞刺激素（α-MSH）对家兔白细胞介素-1β（IL-1β）发热效应及下丘脑组织腺苷环-磷酸（cAMP）含量的影响；同时观察了下丘脑组织体外培养过程中，α-MSH对IL-1β刺激下丘脑释放cAMP的影响。结果显示：α-MSH能显著降低IL-1β引起的体温升高（P＜0．05）；同时抑制下丘脑组织cAMP含量的增高（P＜0．01）。IL-1β与下丘脑组织培养，其上清液中cAMP含量明显升高（P＜0．01）；而预先加入α-MSH，再加同量IL-1β培养，则培养上清液的cAMP含量接近对照组。体内外实验表明，α-MSH抑制中枢发热介质cAMP，的生成可能是其解热的重要机制之一.

关键词： 黑色素细胞刺激素; 白细胞介素-1; 腺苷环-磷酸; 下丘脑; 发热

Cui Hong

First Clinical Institute，China Medical University. Shenyang 110001,Liaoning, China

Abstract

The effect of α- melanocyte-sitmulating hormone (α-MSH ) on IL-1βinduced feverand release of hypothalaminc cAMP was observed in the present work. The results showedthat α-MSH markedly suppressed febrile response (P<0.05) and decreased the cAMPcontent in hgpothalamus in response to icy injection of IL-1β (P<0.01).The cAMPcontent of the medium in which the hypothalamic was incubated for 40 min in thepresence of IL-1βwas significantly increased (P<0.01). However, this increase actioncould be prevented by a pretreatment with α-MSH. The results indicate that the inhibitoryeffect of α-MSH on the enhanced synthesis and release of cAMP in hypothalamus exposedto IL-1β mingt be one of the mechanisms of suppressing fever induced by IL-1β.

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引用本文：

胡巢凤, 王华东, 王达安, 王彦平, 李楚杰. α-黑色素细胞刺激素对白细胞介素-1β发热的解热机理研究[J]. 生理学报 1998; 50 (5): .

Cui Hong. . Acta Physiol Sin 1998; 50 (5): (in Chinese with English abstract).