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八肽胆囊收缩素对吗啡抑制大鼠离体空肠电与收缩活动的对抗作用

徐满英, 杨冬晓, 王淑珍, 金宏波, 邹向辉, 杨新平, 韩济生

哈尔滨医科大学生理教研室；上海黄浦区中心医院外科；北京医科大学生理教

摘要

本研究探讨了八肽胆囊收缩素（CCK－8）对抗吗啡对大鼠离体空肠电与收缩活动的作用。结果表明，吗啡能抑制ACh对空肠峰波发放和收缩的加强作用；CCK－8可对抗吗啡的作用；在此基础上，CCK－A受体桔抗剂devazepide（10nmol／L）能完全翻转CCK－8的抗吗啡作用，但是CCK－B受体拮抗剂L365，260在10nmol／L时可部分翻转、在30nmol／L时能完全翻转CCK－8的作用。上述结果证实，CCK－8的抗吗啡作用是由CCK－A和CCK－B两种受体介导实现的。

关键词： 八肽胆囊收缩素; CCK受体; 拮抗剂; 空肠; 电活动; 收缩

Cui Hong

First Clinical Institute，China Medical University. Shenyang 110001,Liaoning, China

Abstract

in the present investigation, antagonistic action of cholecystokinin octapeptide (CCK-8)against morphine on the electrical and contractile activity of rat jejunum in vitro was studied. The results showed that the potentiation of acetylcholine (ACh) on both the burst of spike and the contractility were inhibited by morphine, which could be complete angagonized by CCK-8. The CCK-8 effect, again, could be suppressed by CCX-A receptor antagonist devazepide (10mol/L), but partially by CCX-B receptor antagonist L-365,260 at 10 nmol/L or completely at concentration of 30 mol/L. The above results demonstrated that the antagonism of CCK-8 on morphine was mediated by both CCK-A and CCK-B receptors.

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引用本文：

徐满英, 杨冬晓, 王淑珍, 金宏波, 邹向辉, 杨新平, 韩济生. 八肽胆囊收缩素对吗啡抑制大鼠离体空肠电与收缩活动的对抗作用[J]. 生理学报 1998; 50 (4): .

Cui Hong. . Acta Physiol Sin 1998; 50 (4): (in Chinese with English abstract).