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大鼠心率变异性频谱中高频成分的中枢机理分析

沈霖霖, 曹银祥, 吴国强, 李鹏

上海医科大学生理学教研室；上海医科大学生物医学工程教研室

摘要

本文探讨心率变异性（heartratevariability，HRV）频谱中高频成分的中枢机理。对正常SD大鼠给予不同频率的人工通气并电刺激延髓疑核，观察HRV频谱的改变，记录与呼吸节律同步的延髓头端腹外侧区（rostralventrolateralmedulla,rVLM）及其周围区神经元细胞外单位放电，对HRV和放电变异性进行相干函数分析。结果显示：（1）HRV的高频成分的中心频率随着人工通气频率的增加而增加，呈高度线性相关，（r=0.83，P＜0．0001）；（2）对rVLM及其周围区与呼吸节律同步的神经元细胞外单位放电和HRV同时进行频谱分析，两者的高频峰呈良好的相关，相干系数k2=0．854±0．1；（3）间断电刺激延髓疑核时，HRV高频成分显著增加。实验直接提示rVLM区参与对HRV的高频调节，HRV的高频成分反映了迷走中枢的波动性活动。

关键词： 大鼠; 心率变异性; 神经元放电变异性; 疑核; 谱分析; 延髓头端腹外侧区

Cui Hong

First Clinical Institute，China Medical University. Shenyang 110001,Liaoning, China

Abstract

Experiments were performed on 15 Sprague-Dawley rats to detect the effect of artificial ventilation of different frequencies on the high frequency component of heart rate variability(HRV) by autoregressive modeling with Burg algorithm. With continuous or intermittent electrical stimulation, different patterns of regulating activity of nucleus ambiguus in medulla on HRV were observed. Fast Fourier transform was used to analyze the coherence between neuronal discharge with respiratory rhythm in rosral ventrolateral medulla (rVLM) and HRV. The results showed that (1) the central frequence of high frequency (HF) component of HRV were moved closely with frequencies of artificial ventilation, (r = 0.83, P < 0.0001); (2) there was a favorable coherence between neuronal discharge with respiratory rhythm in rVLM and HRV in HF on spectrum, (k2 =0.854±0. 1); (3) the area of HF component in HRV was increased significantly during intermittent electrical stimulation of nucleus ambiguus in medulla.

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引用本文：

沈霖霖, 曹银祥, 吴国强, 李鹏. 大鼠心率变异性频谱中高频成分的中枢机理分析 [J]. 生理学报 1998; 50 (4): .

Cui Hong. . Acta Physiol Sin 1998; 50 (4): (in Chinese with English abstract).