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大鼠中脑导水管周围灰质微量注射孤啡肽对痛和针刺镇痛的影响

王红, 朱崇斌, 曹小定, 吴根诚

上海医科大学医学神经生物学国家重点实验室

摘要

孤啡肽（orphaninFQ，OFQ）是新近发现的神经肽，结构与内阿片肽相似，但作用明显不同。本文采用脑核团内微量注射方法，在大鼠电刺激甩尾测痛模型上，观察OFQ在中脑导水管周围灰质（PAG）内对痛和针刺镇痛的影响。结果表明：PAG内微量注射OFQ可使大鼠痛阈降低，并明显对抗针刺镇痛；另外还发现，OFQ在PAG内还可以对抗μ受体激动剂羟甲芬太尼加强针刺镇痛的效应。本文结果提示，OFQ在PAG内加强动物的痛感受，对抗针刺镇痛。

关键词： 孤啡肽; μ阿片受体; 中脑导水管周围灰质; 针刺镇痛; 痛

Cui Hong

First Clinical Institute，China Medical University. Shenyang 110001,Liaoning, China

Abstract

Orphanin Fo (OFQ) is a newly-discovered neuropeptide which shares great simliar sequence with endogenous opioid peptide but with different functions. The present study was to investigate the role of OFQ dricroinjected in the periaqueductal gray (PAG) on pain threshold and acupuncture analgesia (AA) using tail flick tests. The results show that the hyperalgesia of OFQ and its antagonization on AA in PAG are dose-related. OFQ in PAG decreases the enhancing effect on AA induced by ohlnefentanyl, a selective μreceptor agonist. These observations suggest that OFQ in PAG can increase the rat pain sensitivity and antagonize AA.

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引用本文：

王红, 朱崇斌, 曹小定, 吴根诚. 大鼠中脑导水管周围灰质微量注射孤啡肽对痛和针刺镇痛的影响 [J]. 生理学报 1998; 50 (3): .

Cui Hong. . Acta Physiol Sin 1998; 50 (3): (in Chinese with English abstract).