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GABA参与兔杏仁体抑制内膝体神经元电活动

杨莉, 董晓蔚, 封茂滋, 吴群英, 周绍慈

华东师范大学脑功能研究室；首都师范大学生物系

摘要

本文采用多管微电极胞外记录技术观察了短纯音引起兔内膝体（MGB）神经元的声反应及刺激杏仁体对声反应的影响，并在此基础上观察电泳GANA及其桔抗剂Biculline的效应。实验结果表明：GABA可以抑制MGB神经元的声反应及自发放电活动，而GABAA拮抗剂Bicuculline的作用则相反；电泳GABA对MGB神经元产生同刺激杏仁体一样的抑制效应，并且这种影响可被Bicuculline翻转；嗅鼻沟后缘听区皮层（auditorycortexbehindtherhinalsulcus，ACBRS）区对MGB神经元的下行抑制也可由于电泳Bicuculline而消失，但甘氨酸拮抗剂Strychnine则无任何影响。由此推断：介导杏仁体抑制MGB神经元声反应的最终递质是GABA。

关键词： 杏仁体; 抑制; 内膝体; CABA

Cui Hong

First Clinical Institute，China Medical University. Shenyang 110001,Liaoning, China

Abstract

On 10 New Zealand White rabbits irnmohilized with Flaxedil, the inhihitory effect of alnygdaloid stimulation on the responses of medial geniculate body (MGB) neurons to tone bursts and the involved neurotransndtter mechanism were investigated with microiontophoresis techniqUe. 'foe results showed that application of GABA could cause a suppression of spontaneous activity of MGB neurons while GABAA antagonist bicuculline had an opPOsite effect. Iontophoretic injection of GABA gave an inhibitory effect on MGB neurons similar to that caused by stimulating foe amygdala or the auditory cortex behind the thinal sulcus (ACBRS), and in particular, the GABA induced suppression could be completely antagonized by application of hicuculline. Taken together, these data suggested that GABA mediated the amygdaloid inhibitory effect. It seemed unlikely that glycine was involved in the effect, since strychnine, a glycine antagonist, could not affect the descending inhibition from ACBRS area.

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引用本文：

杨莉, 董晓蔚, 封茂滋, 吴群英, 周绍慈. GABA参与兔杏仁体抑制内膝体神经元电活动 [J]. 生理学报 1998; 50 (3): .

Cui Hong. . Acta Physiol Sin 1998; 50 (3): (in Chinese with English abstract).