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高血压大鼠不同血管平滑肌肌球蛋白磷酸化和脱磷酸化酶的变化

孙伟, 文允镒, 吴光玉

中国医学科学院基础医学研究所；中国协和医科大学基础医学院

摘要

本文比较了正常和高血压大鼠不同动脉血管肌球蛋白轻链激酶（MICK和依赖Ca2+的钙调素磷酸酶（Ca2+／CaM－PP）活性的变化。结果表明：在自发性高血压大鼠（SHR）不同血管MLCK的活性不同，依次为主动脉（A）＞尾动脉（CA）＞肠系膜动脉（MA）；而在WKY大鼠，该酶在不同血管的活性依次为A＜＜CA＜＜MA。在WKY大鼠，MACa+／CaM-PP活性明显高于SHR．在肾性高血压大鼠（RHR）的不同血管Ca2+／CaM－PP活性与Wistar大鼠比较，无明显差异。上述结果表明：MLCK活性升高或／和Ca2+／CaM－PP活性（或水平）降低可能与血管收缩及高血压发病有关。

关键词： 高血压大鼠; 肌球蛋白轻链激酶; 钙／钙调素依赖性蛋白磷酸酶

MA Yong-Jie

2College of Information Engineering, Taishan Medical University, Taian 271016, China

Abstract

The changes of activities of myosin light chain kinase(MLCK)and Ca2+/CaM-PP in different arterial vessels from hypertensive and normotensive rats were studied.The results were as follows.The MLCK activity of different arteries of spontanous hypertensive rats(SHR)was different with the order of aorta(A)＞＞caudal artery (CA)＞＞mesenteric artery (MA),while in WKY rats the order of activity among different arteries is A＜＜CA and MA and MA Ca2+/CaM-PP is obviously higher than in SHR.In renal hpertensive ras the activities of Ca2+/CaM-PP in different arteries are no quite different from those of the Wistar rats.The above results suggest that higher activities of MLCK or/and lower activity might be related to vasocontraction and hypertension.

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引用本文：

孙伟, 文允镒, 吴光玉. 高血压大鼠不同血管平滑肌肌球蛋白磷酸化和脱磷酸化酶的变化[J]. 生理学报 1998; 50 (1): .

MA Yong-Jie. . Acta Physiol Sin 1998; 50 (1): (in Chinese with English abstract).