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电针对青霉素所致大脑皮层痫样放电的抑制作用

吴定宗, 马建一, 李文珏

上海中医学院生理教研室. 上海

摘要

青霉素置于大鼠大脑皮层感觉运动区所诱发的皮层痫样放电,可被一些“穴位”电针所抑制,表现为放电频率、振幅及时程之减少。青霉素使逆向刺激锥体束所产生的感觉运动皮层表面负波减小,而电针则促进其恢复。因此电针制痫与它促进回返抑制的恢复有关。将微量纳洛酮注入腹腔、脑室及中脑导水管周围灰质、伏隔核均能翻转电针的作用。将纳洛酮直接注入放置青霉素处的皮层感觉运动区,针效亦被阻断。这表明电针制痛中有内啡肽参与。电刺激中脑导水管周围灰质及伏隔核有显著制痫作用。

关键词： 青霉素痫样放电; 电针; 回返抑制; 纳洛酮; 中脑导水管周围灰质; 伏隔核

Inhibitory effect of electro-acupuncture on penicillin-induced cortical epileptiform discharges

Wu Dingzong, Ma Jianyi, Li Wenjue

Department of Physiology, Shanghai College of Traditional Chinese Medicine. Shanghai, China

Abstract

Epileptiform discharges induced by topical application of penicillin on rat's sensory-motor cortex were attenuated after acupuncture of certain “acupoints”, as revealed by reduction of frequency, amplitude and duration of the discharges. Penicillin decreased the surface-negative wave evoked by antidromic stimulation of pyramidal tract, while electroacupuncture facilitated the restoration of such wave, thus the antiepileptic effect of electro-acupuncture was related to its restoration of recurrent inhibition of pyramidal tract. The effect of acupuncture was reversed by microinjection of naloxone into peritoneal cavity, lateral ventricle, periaqueductal gray of midbrain and N.accumbens. Direct injection of naloxone into the cortical site where penicillin was applied also blocked the acupunetural effect, thus suggesting the participation of endorphin in antiepileptic action of acupuncture. A marked antiepileptic effect was observed during stimulation of periaqueductal gray of midbrain and N. accumbens.

Key words: Penicillin-induced epileptiform discharges;Electro-acupuncture;Recurrent inhibition;Nalosone;Periaqueductal gray of midbrain;N. accumbens

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引用本文：

吴定宗, 马建一, 李文珏. 电针对青霉素所致大脑皮层痫样放电的抑制作用[J]. 生理学报 1986; 38 (3): .

Wu Dingzong, Ma Jianyi, Li Wenjue. Inhibitory effect of electro-acupuncture on penicillin-induced cortical epileptiform discharges. Acta Physiol Sin 1986; 38 (3): (in Chinese with English abstract).