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低通气量呼吸对犬左空心肌收缩性的影响

朱广友, 孟竞璧

司法部司法鉴定科学技术研究所；中国中医研究院针灸研究所

摘要

大量的研究表明,急性呼吸衰竭时多伴有心血管功能的损害,但有关急性呼吸衰竭对于左室心肌收缩性的影响所知甚少。本文对开胸麻醉犬在低通气引起呼吸衰竭时,左室心肌收缩性的变化进行了观测和分析。结果表明,在实验组(n=9)低通气呼吸(通气量小于160ml/min/kg,PaO_2小于60mmHg)时,心率(HR)、主动脉平均压(MOP)、左室收缩峰压(LV-SP)、左室内压最大上升速率(dP/dt_(max))、节段心肌发展张力(DT)及其最大发展速率(dT/dt_(max))均显著降低,心肌开始收缩至dp/dt_(max)的时间(t-dp/dt_(max))和至dT/dt_(max)的时间(t-dT/dt_(max))则显著增加,

关键词： 心肌收缩性; 开胸犬; 低通气; 急性呼吸衰竭; 张力弓

Effect of hypoventlation on the left ventricular myocardial contractility in dogs

Zhu Guangyou, Meng Jingbi

Institute of Science and Technology, Jurisdiciton Ministry, PRC；Institute of Acupuncture, Academy of Traditional Chinese Medicine, Beijing

Abstract

Many investigations have shown that acute respiratory failure is often associated with cardiovascular dysfunction, but the underlying mechanism is obscure. The purpose of the present study is to observe the response of the left ventricular myocardial contractility to acute respiratory failure produced by hypoventilation in open-chest and anesthetized dogs. The results showed that in the experimental group (n=9) hypoventilation (minute volume<160 ml/min，Pa0_(2)<60 mmHg) caused significant decreases in heart rate (P<0.01), mean aortic pressure (P<0.05), systolic pressure and maximal rate of rise (dp/dtmax) (P<0.05), tension of regional myocardium (P<0.01) and maximal rate of rise (dT/dt_(max)) (P<0.001) but significant increases in the time to dp/dt_(max), (t-dp/dt_(max)) (P<0.05) and the time to dT/dtmaa (t-dT/dt_(max)) (P<0.O1), while in the control group (n-5) with normoventilation (minute volume>450 ml/min-kg, PaO_(2)>70 mmHg), there were no changes in aforementioned indexes during 45 minutes of experimentation. The result of the present study indicates that the left ventricular myocardial contractility is severely damaged during acute respiratory failure.

Key words: Myocardial contractility;Open-chest dogs;Hypoventilation;Acute respi ratory failure;Strain guage arch

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引用本文：

朱广友, 孟竞璧. 低通气量呼吸对犬左空心肌收缩性的影响[J]. 生理学报 1987; 39 (5): .

Zhu Guangyou, Meng Jingbi. Effect of hypoventlation on the left ventricular myocardial contractility in dogs. Acta Physiol Sin 1987; 39 (5): (in Chinese with English abstract).