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硝普钠造成狗低血压时脑内注射东莨菪碱对电针升压作用的影响

肖永福, 李鹏

上海第一医学院生理学教研室. 上海

摘要

于14条清醒狗静脉内匀速注射硝普钠造成急性实验性低血压时(动脉收缩压从131±6mmHg 降至94±4mmHg),在中脑中央灰质、下丘脑腹内侧核区、中脑中缝核旁网状结构微量注射东莨菪碱20μg(溶于2μl生理盐水),可以阻断电针的升压作用。如果在低血压清醒狗中于上述中枢部位微量注射乙酰胆碱(ACh)200μg(溶于2μl生理盐水),可引起血压明显回升(收缩压从94±4mmHg 升到110±6mmHg,P<0.01),持续约10min。实验结果表明:用舒血管药物造成实验性低血压时,电针引起的升压作用与中脑中央灰质、下丘脑腹内侧核区、中脑中缝核旁网状结构等部位的胆碱能M受体的激活有关

关键词： 电针; 硝普钠; 东莨菪碱; 中脑中央灰质; 下丘脑腹内侧核

Influence of microinjection of scopolamine into various brain areas on pressor effect of electroacupuncture in nitropressideinduced hypotensive dogs

Xiao Yongfu, Li Peng

Department of Physiology, Shanghai First Medical College. Shanghai, China

Abstract

In 14 conscious dogs implanted with stainless steel cannulae, the effect of microinjection of the cholinergic agonist or antagonist into various brain areas on the pressor effect of electroacupuncture (EA) was investigated. Following microinjection of scopolamine (20 #mu#g dissolved in 2 #mu#l isotonic saline) into the midbrain central gray (CG), the midbrain reticular formation (RF) and the ventromedial hypothalamus (VMH) in hypotensive dogs induced by infusion of sodium nitroprusside (NP), the pressor effect of EA was blocked. On the other hand, acetylcholine (ACh, 200 #mu#g dissolved in 2 #mu#l isotonic saline) microinjected into those areas elicited a pressor effect (P<0.01), which lasted about 10 min. It is suggested that the pressor effect of EA during NP hypotension was mediated by the activation of the muscarinic receptors in CG, RF and VMH.

Key words: Electroacupuncture;Nitroprusside;Scopolamine;Midbrain central gray;Ventromedial hypothalamus

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引用本文：

肖永福, 李鹏. 硝普钠造成狗低血压时脑内注射东莨菪碱对电针升压作用的影响[J]. 生理学报 1985; 37 (1): .

Xiao Yongfu, Li Peng. Influence of microinjection of scopolamine into various brain areas on pressor effect of electroacupuncture in nitropressideinduced hypotensive dogs. Acta Physiol Sin 1985; 37 (1): (in Chinese with English abstract).