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刺激杏仁基底外侧核对外侧缰核神经元单位放电的影响

刘伟民, 王绍

白求恩医科大学生理教研室

摘要

用玻璃微电极细胞外记录大鼠外侧缰核(LHN)神经元的单位放电。共记录了110个神经元。其中痛兴奋神经元(LHPE)75个;痛抑制神经元(LHPI)11个;广动力型神经元2个;无反应神经元17个;此外还有5个对躯体与内脏伤害性刺激反应不同的神经元。电刺激杏仁基底外侧核(以下简称杏仁核,AMG)对LHPE和LHPI的自发放电主要产生抑制作用,分别占总数的81.1%和72.7%,并抑制其对伤害性刺激的反应;对无反应神经元和广动力型神经元无明显影响。AMG内微量注射吗啡能抑制LHPE的伤害性刺激反应,但对其自发放电无明显影响。

关键词： 杏仁基底外侧核; 外侧缰核; 伤害性刺激反应; 吗啡; 纳洛酮

Effect of stimulation of basolateral amygdaloid nucleus on unit discharges of neurons of habenular nucleus

Liu Weimin, Wang Shao

Department of Physiology, Norman Bethune University of Medical Sciences

Abstract

In 46 albino rats under chloral hydrate anesthesia, 110 neurons of lateral
habenular nucleus (LHN) were extracellularly recorded. Spontaneous discharge
frequencies were increased in 75 neurons (LHPE), decreased in 11 (LHPI), unchanged in 17 (pain-nonsensitive neurons) by both somatic and visceral noxious stimulation; 2 neurons (wide-dynamic neurons) were activated by either
noxious stimulation or non-noxious stimulation; 5 neurons had different esponses
to somatic and visceral noxious stimulation. Spontaneous discharge frequencies of LHPE and LHPI neurons were decreased and the nociceptive responses of them were inhibited by stimulation of basolateral amygdoloid nucleus (AMG). There was no effect of stimulation of AMG on pain-nonsensitive neurons and wide-dynamic neurons of LHN. Microinjection of morphine into AMG could inhibit the nociceptive responses of LHPE. Intra-amygdaloid naloxone injection could increase the frequency of spontaneous discharges of LHPE and intensify its nociceptive responses. Microinjection of naloxone could also relieve the inhibitory effect of electroacupuncture on nociceptive responses of LHPE.

Key words: Basolateral amygdoloid nucleus;Iateral habenular nucleus;Nociceptive response;Morphine;Naloxone

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引用本文：

刘伟民, 王绍. 刺激杏仁基底外侧核对外侧缰核神经元单位放电的影响[J]. 生理学报 1987; 39 (4): .

Liu Weimin, Wang Shao. Effect of stimulation of basolateral amygdaloid nucleus on unit discharges of neurons of habenular nucleus. Acta Physiol Sin 1987; 39 (4): (in Chinese with English abstract).