ISSN 0371-0874, CN 31-1352/Q

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帕金森病大鼠中缝背核5-羟色胺能神经元放电频率和放电形式的变化

褚玉霞, 刘健, 冯洁, 王勇, 张巧俊, 李强

西安交通大学医学院生理学教研室;环境与疾病相关基因教育部重点实验室. 西安 710061

摘要

实验采用玻璃微电极细胞外记录法,观察了帕金森病(Parkinson's disease,PD)大鼠中缝背核(dorsal raphe nucleus,DRN)5-羟色胺(5-hydroxytrypamine,5-HT)能神经元电活动的变化.结果发现,对照组和PD组大鼠DRN中5-HT能神经元的放电频率分别为(1.61±0.56)Hz和(2.61±1.97)Hz,PD组大鼠的放电频率显著高于对照组(P<0.05)。

关键词: 帕金森病; 中缝背核; 5-羟色胺; 6-羟多巴胺; 电生理学; 大鼠

Changes of discharge rate and pattern of 5-hydroxytrypamine neurons of dorsal raphe nucleus in a rat model of Parkinson's disease

Chu Yuxia, Liu Jian, Feng Jie, Wang Yong, Zhang Qianjun, Li Qiang

Department of Physiology, School of Medicine. Xi'an Jiao Tong University;Key Laboratory of Enviorment and Genes Related to Disease. Xi'an 710061, China;Department of Neurology, the Second Hospital, Xi'an Jiao Tong University. Xi'an 710004, China

Abstract

In the present study, changes of the neuronal activity of 5-hydroxytrypamine (5-HT) neurons of dorsal raphe nucleus (DRN) in a rat model of Parkinson's disease (PD) were investigated with glass microelectrode recording. The results showed that the discharge rates of 5-HT neurons in control and PD rats were (1.61±0.56) Hz and (2.61±1.97) Hz, respectively.

Key words: Parkinson's disease;Dorsal raphe nucleus;5-hydroxytrypamine;6-judrpxudopamine;Electrophysiology;Rat

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引用本文:

褚玉霞, 刘健, 冯洁, 王勇, 张巧俊, 李强. 帕金森病大鼠中缝背核5-羟色胺能神经元放电频率和放电形式的变化[J]. 生理学报 2004; 56 (5): .

Chu Yuxia, Liu Jian, Feng Jie, Wang Yong, Zhang Qianjun, Li Qiang. Changes of discharge rate and pattern of 5-hydroxytrypamine neurons of dorsal raphe nucleus in a rat model of Parkinson's disease. Acta Physiol Sin 2004; 56 (5): (in Chinese with English abstract).