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肾上腺素能受体阻断剂预防慢性压力超负荷左心室的电重构

王军奎, 崔长琮, 张虹, 姚青海, 姚晓伟, 陈新义

西安交通大学第一医院心内科,西安,710061；陕西省人民医院心内科,西安,710068

摘要

研究长期使用肾上腺素能受体阻断剂治疗对慢性压力超负荷左心室电重构的影响.新西兰兔通过肾上腹主动脉次全结扎诱发慢性压力超负荷,10周后行心脏超声检查,并采用全细胞膜片钳技术分别记录腹主动脉结扎组(简称结扎组)、腹主动脉结扎+Carvedilol干预组(简称Carvedilol组)及正常对照组(简称对照组)动物左室肌中层细胞的动作电位(action potential,AP)、内向整流钾电流(inward rectifier potassium current,IKi)、延迟整流钾电流(delayed rectifier potassium current,Ik)及Na+/Ca2+交换体电流.结果表明,结扎组的左室质量指数较对照组明显升高,Carvedilo1组较结扎组明显降低(P＜0.01)。

关键词： 生理学; 膜片钳技术; Carvedilol; 心室重构; 离子通道

Adrenergic receptor antagonist prevents the left ventricle with chronic pressure-overload from electrical remodeling

Wu Bowei

Department of Pharmacology ShanXi Medical University. Taiyuan, Shanxi 030001, China

Abstract

Experiments were performed to investigate the effects of long-term treatment with adrenergic receptor antagonist on electrical remodeling of the left ventricle with chronic pressure-overload. New Zealand rabbits underwent subtotal banding of superrenal abdominal aorta. At 10 weeks after surgery, echocardiography examination was performed, then action potential (AP), inward rectifier potassium current (Ikj), delayed rectifier potassium current (IK) and Na+/Ca2+ exchanger current (INa+/Ca2+) were recorded in midmyocardial cells isolated from left ventricle of abdominal aorta banded group (banded group), abdominal aorta banding plus Carvedilol intervention group (Carvedilol group), and normal control group rabbits by using the whole-cell patch-clamp techniques. The results showed that left ventricular mass index in control, banded, and Carvedilol groups were 1.78±0.06 (n=7), 2.33±0.11 (n=7), and 1.87±0.08 (n=7), respectively (banded vs control and Carvedilol, P＜0.01).

Key words: P0hysiology;Patch-clamp techniques;Carvedilol;Ventricular remodeling;Ionic channel

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引用本文：

王军奎, 崔长琮, 张虹, 姚青海, 姚晓伟, 陈新义. 肾上腺素能受体阻断剂预防慢性压力超负荷左心室的电重构[J]. 生理学报 2004; 56 (4): .

Wu Bowei. Adrenergic receptor antagonist prevents the left ventricle with chronic pressure-overload from electrical remodeling. Acta Physiol Sin 2004; 56 (4): (in Chinese with English abstract).