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多巴胺D_(1)和D_(2)受体拮抗剂对针刺镇痛的增强

汪海宏, 许绍芬

上海医科大学神经生物学教研室. 上海 200032

摘要

在兔K~(+)透入测痛模型上,应用高选择性的D_(1)或D_(2)受体拮抗剂、观察其对针刺镇痛的影响。结果表明,iv.D_(2)受体拮抗剂氟哌啶醇和氯氮平加强针刺镇痛,且与剂量有关。icv. D_(2)受体拮抗剂domperidone和舒必利及D_(1)受体拮抗剂SCH23390,亦能加强针刺镇痛。该文对D_(1)和D_(2)受体拮抗剂在针刺镇痛中的作用进行了讨论。

关键词： 多巴胺受体; 针刺镇痛; 氟哌啶醇; 氯氮平; Domperidone; 舒必利; SCH23390

Effect of D_(1) amd D_(2) dopamine receptor antagonists on acupuncture analgesia

Wang Haihong, Xu Shaofeng

Department of Neurobiology, Shanghai Medical University. Shanghai 200032, China

Abstract

Some highly selective D_(1) or D_(2),receptor antagonists were tested on rabbit skin pain model to investigate the effect of the subtypes of dopamine receptor on acupuncture analgesia. It was found that iv. of D_(2) receptor antagonists haloperidol and clozapine，had a potentiating effect on acupuncture analgesia. lcv. of D_(2) receptor antagonists domperidone and sulpiride and D_(1) receptor antagonist SCH23390, also enhanced acupuncture analgesia markedly. The effect of D_(1) and D_(2) receptor on acupuncture analgesia was discussed.

Key words: Dopamine receptor;Acupuncture analgesia;Haloperidol;Clozapine;Domperidone;Sulpiride;SCH23390

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引用本文：

汪海宏, 许绍芬. 多巴胺D_(1)和D_(2)受体拮抗剂对针刺镇痛的增强[J]. 生理学报 1993; 45 (1): .

Wang Haihong, Xu Shaofeng. Effect of D_(1) amd D_(2) dopamine receptor antagonists on acupuncture analgesia. Acta Physiol Sin 1993; 45 (1): (in Chinese with English abstract).